A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Study Purpose
The purpose of the study is to see how effective JNJ-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years and Over |
Gender | All |
Inclusion Criteria:
- - Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention.
- - Total body surface area (BSA) greater than or equal to (>=)10 percent (%) at screening and baseline.
- - Total psoriasis area and severity index (PASI) >=12 at screening and baseline.
- - Total investigator global assessment (IGA) >=3 at screening and baseline.
- - Candidate for phototherapy or systemic treatment for plaque psoriasis.
Exclusion Criteria:
- - Nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular) - Current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) - A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances.
- - Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib, or to any of the excipients or components of the study intervention.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT06143878 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Janssen Research & Development, LLC |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Janssen Research & Development, LLC Clinicaltrial |
Principal Investigator Affiliation | Janssen Research & Development, LLC |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Argentina, Australia, Brazil, Canada, Germany, Hungary, Japan, Korea, Republic of, Poland, Spain, Taiwan, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Plaque Psoriasis |
Arms
Experimental: JNJ-77242113
Participants will receive JNJ-77242113 from Week 0 through Week 156 and deucravacitinib matching placebo from Week 0 through Week 24.
Placebo Comparator: Placebo
Participants will receive matching placebo for JNJ-77242113 from Week 0 through Week 16, matching placebo for deucravacitinib from Week 0 through Week 24 and JNJ-77242113 from Week 16 through Week 156.
Active Comparator: Deucravacitinib
Participants will receive deucravacitinib from Week 0 through Week 24 and matching placebo for JNJ-77242113 from Week 0 through Week 24 and JNJ-77242113 from Week 24 through Week 156.
Interventions
Drug: - JNJ-77242113
JNJ-77242113 will be administered orally.
Drug: - JNJ-77242113 Matching Placebo
JNJ-77242113 matching placebo will be administered orally.
Drug: - Deucravacitinib
Deucravacitinib will be administered orally.
Drug: - Deucravacitinib Matching Placebo
Deucravacitinib matching placebo will be administered orally.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Medical Dermatology Specialists
Phoenix, Arizona, 85006
Status
Recruiting
Address
Center for Dermatology and Plastic Surgery
Scottsdale, Arizona, 85260
Status
Recruiting
Address
Johnson Dermatology
Fort Smith, Arkansas, 72916
Status
Recruiting
Address
First OC Dermatology
Fountain Valley, California, 92708
Status
Recruiting
Address
Center for Dermatology Clinical Research
Fremont, California, 94538
Status
Recruiting
Address
Integrative Skin Science and Research
Sacramento, California, 95815
Status
Recruiting
Address
Southern California Dermatology
Santa Ana, California, 92701
Status
Recruiting
Address
Clinical Science Institute
Santa Monica, California, 90404
Status
Recruiting
Address
Driven Research LLC
Coral Gables, Florida, 33134
Status
Recruiting
Address
Ziaderm Research, LLC
North Miami Beach, Florida, 33162
Status
Recruiting
Address
Renstar Medical Research
Ocala, Florida, 34470
Status
Recruiting
Address
Forcare Clinical Research Inc
Tampa, Florida, 33613
Status
Recruiting
Address
Hamilton Research, LLC.
Alpharetta, Georgia, 30022
Status
Recruiting
Address
Skin Care Physicians of Georgia
Macon, Georgia, 31217
Status
Recruiting
Address
Illinois Dermatology Institute - Chicago Loop Office
Chicago, Illinois, 60602
Status
Recruiting
Address
Arlington Dermatology
Rolling Meadows, Illinois, 60008
Status
Recruiting
Address
Northshore Medical Group
Skokie, Illinois, 60077
Status
Recruiting
Address
Dundee Dermatology
West Dundee, Illinois, 60118
Status
Recruiting
Address
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, 46250
Status
Recruiting
Address
Indiana Clinical Trial Center
Plainfield, Indiana, 46168
Status
Recruiting
Address
Dermatology Specialists
Louisville, Kentucky, 40241
Status
Recruiting
Address
Dermatology and Advanced Aesthetics
Lake Charles, Louisiana, 70605
Status
Recruiting
Address
Tufts Medical Center
Boston, Massachusetts, 02111
Status
Recruiting
Address
David Fivenson MD, Dermatology
Ann Arbor, Michigan, 48103
Status
Recruiting
Address
Michigan Center of Medical Research
Clarkston, Michigan, 48346
Status
Recruiting
Address
Henry Ford Medical Center
Detroit, Michigan, 48202
Status
Recruiting
Address
Hamzavi Dermatology
Fort Gratiot, Michigan, 48059
Status
Recruiting
Address
MediSearch Clinical Trials
Saint Joseph, Missouri, 64506
Status
Recruiting
Address
Skin Specialists
Omaha, Nebraska, 68144
Status
Recruiting
Address
Fife Dermatology
Las Vegas, Nevada, 89119
Status
Recruiting
Address
Allcutis Research
Portsmouth, New Hampshire, 03801
Status
Recruiting
Address
Windsor Dermatology
East Windsor, New Jersey, 08520
Status
Recruiting
Address
Schweiger Dermatology Group
Hackensack, New Jersey, 07601
Status
Recruiting
Address
Derm Research Center of New York, Inc.
Stony Brook, New York, 11790
Status
Recruiting
Address
Wilmington Dermatology Center
Wilmington, North Carolina, 28405
Status
Recruiting
Address
Oakview Dermatology
Athens, Ohio, 45701
Status
Recruiting
Address
Optima Research
Boardman, Ohio, 44512
Status
Recruiting
Address
Central Sooner Research
Oklahoma City, Oklahoma, 73170
Status
Recruiting
Address
Oregon Medical Research Center
Portland, Oregon, 97201
Status
Recruiting
Address
Health Concepts
Rapid City, South Dakota, 57702
Status
Recruiting
Address
Modern Research Associates
Dallas, Texas, 75231
Status
Recruiting
Address
Center for Clinical Studies
Houston, Texas, 77004
Status
Recruiting
Address
Austin Institute for Clinical Research
Houston, Texas, 77056
Status
Recruiting
Address
Austin Institute for Clinical Research
Pflugerville, Texas, 78660
Status
Recruiting
Address
Progressive Clinical Research
San Antonio, Texas, 78213
Status
Recruiting
Address
Texas Dermatology and Laser Specialists
San Antonio, Texas, 78218
Status
Recruiting
Address
Center for Clinical Studies
Webster, Texas, 77598
Status
Recruiting
Address
National Clinical Research
Richmond, Virginia, 23294
Status
Recruiting
Address
Frontier Derm Partners CRO, LLC
Mill Creek, Washington, 98012
Status
Recruiting
Address
Premier Clinical Research
Spokane, Washington, 99202
International Sites
Status
Recruiting
Address
Instituto Medico De Alta Complejidad (IMAC)
Buenos Aires, , B1643CRO
Status
Recruiting
Address
ARCIS Salud SRL Aprillus asistencia e investigacion
Buenos Aires, , C1406AGA
Status
Recruiting
Address
Halitus Instituto Medico S.A. - Dermatologia y Estetica
Caba, , C1122AAF
Status
Recruiting
Address
Hospital Italiano de Buenos Aires
Caba, , C1199ABD
Status
Recruiting
Address
Instituto de Neumonologia y Dermatologia
Caba, , C1425BEA
Status
Recruiting
Address
Hospital Italiano de La Plata
La Plata, , B1900AXI
Status
Recruiting
Address
Instituto Caici Srl.
Rosario, , S2000PBJ
Status
Recruiting
Address
Centro de Investigaciones Medicas Tucuman
San Miguel De Tucuman, , T4000AXL
Status
Recruiting
Address
North Eastern Health Specialists
Campbelltown, , 5074
Status
Recruiting
Address
Paratus Clinical Research Woden
Canberra, , 2606
Status
Recruiting
Address
Sinclair Dermatology
East Melbourne, , 3002
Status
Recruiting
Address
Skin Health Institute Inc.
Melbourne, , 3053
Status
Recruiting
Address
Veracity Clinical Research
Woolloongabba, , 4102
Status
Recruiting
Address
Fundacao do ABC - Centro Universitario FMABC
Santo Andre, , 09060-870
Status
Recruiting
Address
Enverus Medical
Surrey, British Columbia, V3V 0C6
Status
Recruiting
Address
Karma Clinical Trials Inc.
St. John's, Newfoundland and Labrador, A1A 4Y3
Status
Recruiting
Address
CCA Medical Research Corporation
Ajax, Ontario, L1S7K8
Status
Recruiting
Address
SimcoDerm Medical and Surgical Dermatology Centre
Barrie, Ontario, L4M 7G1
Status
Recruiting
Address
Dermatrials Research
Hamilton, Ontario, L8N 1Y2
Status
Recruiting
Address
York Dermatology Clinic and Research Centre
Richmond Hill, Ontario, L4C 9M7
Status
Recruiting
Address
Alliance Clinical Trials
Waterloo, Ontario, N2J 1C4
Status
Recruiting
Address
XLR8 Medical Research
Windsor, Ontario, N8T 1E6
Status
Recruiting
Address
ISA - Interdisciplinary Study Association GmbH
Berlin, , 10789
Status
Recruiting
Address
Hautarztpraxis
Bramsche, , 49565
Status
Recruiting
Address
Klinische Forschung Dresden GmbH
Dresden, , 01069
Status
Recruiting
Address
Praxis für Dermatologie und Venerologie
Dresden, , 01097
Status
Recruiting
Address
Universitaetsklinikum Duesseldorf
Duesseldorf, , 40225
Status
Recruiting
Address
Universitaetsklinikum Hamburg Eppendorf
Hamburg, , 20246
Status
Recruiting
Address
MensingDerma research GmbH
Hamburg, , 22391
Status
Recruiting
Address
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel, , 24105
Status
Recruiting
Address
Studienzentrum Dr Schwarz Germany
Langenau, , 89129
Status
Recruiting
Address
Universitatsklinikum Leipzig AOR
Leipzig, , 04103
Status
Recruiting
Address
Universitatsklinikum Schleswig Holstein Campus Lubeck
Lubeck, , 23562
Status
Recruiting
Address
Universitaetsklinikum Mannheim
Mannheim, , 68167
Status
Recruiting
Address
Klinik und Poliklinik fur Dermatologie und Allergologie am Biederstein
Munchen, , 80802
Status
Recruiting
Address
Hautarztpraxis
Potsdam, , 14467
Status
Recruiting
Address
Universitaetsmedizin Rostock
Rostock, , 18057
Status
Recruiting
Address
Pecsi Tudomanyegyetem
Borgyogyaszati Klinika, , 7632
Status
Recruiting
Address
Obudai Egeszsegugyi Centrum Kft
Budapest, , 1036
Status
Recruiting
Address
Derma-B Kft
Debrecen, , 4031
Status
Recruiting
Address
Debreceni Egyetem Klinikai Kozpont
Debrecen, , 4032
Status
Recruiting
Address
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Kaposvar, , 7400
Status
Recruiting
Address
SZTE AOK Szent-Gyorgyi Albert Klinikai Kozpont, Borgyogyaszati és Allergologiai Klinika
Szeged, , 6720
Status
Recruiting
Address
Allergo-Derm Bakos Kft.
Szolnok, , 5000
Status
Recruiting
Address
Medmare Egeszsegugyi Es Szolgaltato Bt.
Veszprem, , 8200
Status
Recruiting
Address
Fukuoka University Hospital
Fukuoka, , 814-0180
Status
Recruiting
Address
Hino Dermatology Clinic
Fukutsu, , 811-3217
Status
Recruiting
Address
Gifu University Hospital
Gifu, , 501-1112
Status
Recruiting
Address
Gunma University Hospital
Gunma, , 371 8511
Status
Recruiting
Address
JR Sapporo Hospital
Hokkaido, , 060-0033
Status
Recruiting
Address
Asahikawa Medical University Hospital
Hokkaido, , 078 8510
Status
Recruiting
Address
Tokai University Hospital
Isehara, , 259-1193
Status
Recruiting
Address
Teikyo University Hospital
Itabashi Ku, , 173 8606
Status
Recruiting
Address
St Marianna University Hospital
Kawasaki City, , 216-8511
Status
Recruiting
Address
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, , 807-8556
Status
Recruiting
Address
Nagoya City University Hospital
Nagoya, , 467 8602
Status
Recruiting
Address
University of the Ryukyus Hospital
Nishihara, , 903-0125
Status
Recruiting
Address
Takagi Dermatology Clinic
Obihiro-shi, , 080-0013
Status
Recruiting
Address
Kindai University Hospital
Osaka Sayama shi, , 589 8511
Status
Recruiting
Address
Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital
Osaka, , 550 0006
Status
Recruiting
Address
Kume Clinic
Sakai-shi, , 593-8324
Status
Recruiting
Address
Sapporo Skin Clinic
Sapporo shi, , 060 0063
Status
Recruiting
Address
Tohoku University Hospital
Sendai, , 980-8574
Status
Recruiting
Address
Osaka University Hospital
Suita-shi, , 565-0871
Status
Recruiting
Address
Jitaikai Tachikawa dermatology clinic
Tachikawa, , 190 0023
Status
Recruiting
Address
Shirasaki Dermatology Clinic
Takaoka-shi, , 933-0871
Status
Recruiting
Address
Tokyo Medical University Hospital
Tokyo, , 160-0023
Status
Recruiting
Address
Mie University Hospital
Tsu, , 514 8507
Status
Recruiting
Address
Pusan National University Hospital
Busan, , 49241
Status
Recruiting
Address
Seoul National University Bundang Hospital
Gyeonggi-do, , 13620
Status
Recruiting
Address
Seoul National University Hospital
Seoul, , 03080
Status
Recruiting
Address
Hanyang University Medical Center
Seoul, , 04763
Status
Recruiting
Address
Konkuk University Medical Center
Seoul, , 05030
Status
Recruiting
Address
The Catholic University of Korea Seoul St. Mary's Hospital
Seoul, , 06591
Status
Recruiting
Address
Kyung Hee University Hospital
Seoul, , 130 050
Status
Recruiting
Address
Specderm Poznanska sp j
Bialystok, , 15 375
Status
Recruiting
Address
Osteo-Medic s.c A. Racewicz, J Supronik
Bialystok, , 15-351
Status
Recruiting
Address
Centrum Kliniczno Badawcze J. Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka Partnerska
Elblag, , 82-300
Status
Recruiting
Address
Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna
Krakow, , 30 002
Status
Recruiting
Address
Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny
Krakow, , 30-438
Status
Recruiting
Address
Centrum Medyczne Promed
Krakow, , 31-411
Status
Recruiting
Address
Dermed Centrum Medyczne Sp z o o
Lodz, , 90 265
Status
Recruiting
Address
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna
Lodz, , 90-338
Status
Recruiting
Address
DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.
Osielsko, , 86031
Status
Recruiting
Address
SOLUMED Centrum Medyczne
Poznan, , 60-529
Status
Recruiting
Address
Clinical Research Center sp z o o MEDIC R s k
Poznan, , 61 731
Status
Recruiting
Address
Przychodnia Specjalistyczna High Med
Warszawa, , 01 817
Status
Recruiting
Address
Klinika Ambroziak Dermatologia
Warszawa, , 02-953
Status
Recruiting
Address
DERMMEDICA Sp.z o.o.
Wroclaw, , 51 503
Status
Recruiting
Address
Centrum Medyczne Oporow
Wroclaw, , 52-416
Status
Recruiting
Address
WroMedica I.Bielicka, A.Strzałkowska s.c.
Wrocław, , 51-685
Status
Recruiting
Address
Hosp. Gral. Univ. Dr. Balmis
Alicante, , 03010
Status
Recruiting
Address
Hosp. Univ. de Cruces
Barakaldo, , 48902
Status
Recruiting
Address
Hosp. de La Santa Creu I Sant Pau
Barcelona, , 08041
Status
Recruiting
Address
Hosp. Univ. San Cecilio
Granada, , 18016
Status
Recruiting
Address
Hosp. Univ. de Bellvitge
L'Hospitalet de Llobregat, , 08907
Status
Recruiting
Address
Hosp. Univ. de La Princesa
Madrid, , 28006
Status
Recruiting
Address
Pedro Jaen Group
Madrid, , 28006
Status
Recruiting
Address
Hosp. Gral. Univ. Gregorio Maranon
Madrid, , 28007
Status
Recruiting
Address
Hosp. Univ. Infanta Leonor
Madrid, , 28031
Status
Recruiting
Address
Hosp. Univ. 12 de Octubre
Madrid, , 28041
Status
Recruiting
Address
Hosp. Univ. de La Paz
Madrid, , 28046
Status
Recruiting
Address
Hosp. Univ. I Politecni La Fe
Valencia, , 46026
Status
Recruiting
Address
National Taiwan University Hospital Hsin-Chu Branch
Hsin Chu, , 30059
Status
Recruiting
Address
Chang Kung Memorial Hospital
Kaohsiung City, , 833
Status
Recruiting
Address
Taipei Medical University Shuang Ho Hospital
New Taipei City, , 235
Status
Recruiting
Address
National Taiwan University Hospital
Taipei, , 10048
Status
Recruiting
Address
Taipei Mackay Memorial Hospital
Taipei, , 10449
Status
Recruiting
Address
Taipei Veterans General Hospital
Taipei, , 112
Status
Recruiting
Address
Linkou Chang Gung Memorial Hospital
Taoyuan, , 33382
Status
Recruiting
Address
Guy's and St Thomas' NHS Foundation Trust
London, , SE1 9RT
Status
Recruiting
Address
Royal Berkshire Hospital
Reading, , RG1 5AN
Status
Recruiting
Address
Salford Royal Hospital
Salford, , M6 8HD
Status
Recruiting
Address
University Hospital Southampton NHS Foundation Trust
Southampton, , SO16 6YD