Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In Psoriasis

Study Purpose

This is a Phase 2b, randomized, double blind, vehicle controlled, parallel group, multicenter study in participants with mild to moderate plaque psoriasis. The duration of study participation will be approximately 22 weeks, including up to a 6 week screening period, 12 week treatment period, and approximately 4 week follow up period. Approximately 280 participants are planned to be randomized into the study.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - plaque psoriasis for 6 months.
  • - PGA score mild or moderate.
  • - body surface area (BSA) 2-15%

    Exclusion Criteria:

    - other skin conditions that would interfere with the evaluation of psoriasis.
  • - history of herpes zoster or simplex.
- Infected with Mycobacterium tuberculosis

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03850483
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Pfizer
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Pfizer CT.gov Call Center
Principal Investigator Affiliation Pfizer
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Australia, Bulgaria, Canada, Denmark, Germany, Hungary, Japan, Latvia, Poland, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Psoriasis
Study Website: View Trial Website
Arms & Interventions

Arms

Placebo Comparator: Vehicle cream QD

Vehicle cream applied once daily (QD)

Experimental: PF-06700841 0.1% cream QD

PF-06700841 0.1% cream applied once daily (QD)

Experimental: PF-06700841 0.3% cream QD

PF-06700841 0.3% cream applied once daily (QD)

Experimental: PF-06700841 1% cream QD

PF-06700841 1% cream applied once daily (QD)

Experimental: PF-06700841 3% cream QD

PF-06700841 3% cream applied once daily (QD)

Experimental: PF-06700841 0.3% cream BID

PF-06700841 0.3% cream applied twice daily (BID)

Experimental: PF-06700841 1% cream BID

PF-06700841 1% cream applied twice daily (BID)

Placebo Comparator: Vehicle cream BID

Vehicle cream applied twice daily (BID)

Experimental: PF-06700841 3% cream BID

PF-06700841 3% cream applied twice daily (BID)

Interventions

Drug: - PF-06700841

PF-06700841 topical cream

Drug: - Vehicle (Placebo)

Vehicle topical cream

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Scottsdale, Arizona

Status

Active, not recruiting

Address

Center for Dermatology and Plastic Surgery/CCT

Scottsdale, Arizona, 85260

Scottsdale, Arizona

Status

Active, not recruiting

Address

Center for Dermatology and Plastic Surgery

Scottsdale, Arizona, 85260

Burke Pharmaceutical Research, Hot Springs, Arkansas

Status

Active, not recruiting

Address

Burke Pharmaceutical Research

Hot Springs, Arkansas, 71913

Anaheim Clinical Trials, LLC, Anaheim, California

Status

Active, not recruiting

Address

Anaheim Clinical Trials, LLC

Anaheim, California, 92801

California Skin Institute, Anaheim, California

Status

Active, not recruiting

Address

California Skin Institute

Anaheim, California, 92801

Encinitas, California

Status

Active, not recruiting

Address

California Dermatology & Clinical Research Institute

Encinitas, California, 92024

First OC Dermatology, Fountain Valley, California

Status

Active, not recruiting

Address

First OC Dermatology

Fountain Valley, California, 92708

Clinical Science Institute, Santa Monica, California

Status

Active, not recruiting

Address

Clinical Science Institute

Santa Monica, California, 90404

New England Research Associates, LLC, Bridgeport, Connecticut

Status

Active, not recruiting

Address

New England Research Associates, LLC

Bridgeport, Connecticut, 06606

Dermatology Physicians of Connecticut, Shelton, Connecticut

Status

Active, not recruiting

Address

Dermatology Physicians of Connecticut

Shelton, Connecticut, 06848

Olympian Clinical Research, Clearwater, Florida

Status

Active, not recruiting

Address

Olympian Clinical Research

Clearwater, Florida, 33756

DeLand, Florida

Status

Active, not recruiting

Address

Accel Research Sites - DeLand Clinical Research Unit

DeLand, Florida, 32720

Jacksonville, Florida

Status

Active, not recruiting

Address

Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216

Renstar Medical Research, Ocala, Florida

Status

Active, not recruiting

Address

Renstar Medical Research

Ocala, Florida, 34470

MidState Skin Institute, Ocala, Florida

Status

Active, not recruiting

Address

MidState Skin Institute

Ocala, Florida, 34471

Renstar Medical Research, Ocala, Florida

Status

Active, not recruiting

Address

Renstar Medical Research

Ocala, Florida, 34471

Park Avenue Dermatology, PA, Orange Park, Florida

Status

Active, not recruiting

Address

Park Avenue Dermatology, PA

Orange Park, Florida, 32073

ForCare Clinical Research, Tampa, Florida

Status

Active, not recruiting

Address

ForCare Clinical Research

Tampa, Florida, 33613

Dundee Dermatology, West Dundee, Illinois

Status

Active, not recruiting

Address

Dundee Dermatology

West Dundee, Illinois, 60118

DS Research, Clarksville, Indiana

Status

Active, not recruiting

Address

DS Research

Clarksville, Indiana, 47129

DS Research, Louisville, Kentucky

Status

Active, not recruiting

Address

DS Research

Louisville, Kentucky, 40241

Meridian Clinical Research, LLC, Baton Rouge, Louisiana

Status

Active, not recruiting

Address

Meridian Clinical Research, LLC

Baton Rouge, Louisiana, 70808

MediSearch Clinical Trials, Saint Joseph, Missouri

Status

Active, not recruiting

Address

MediSearch Clinical Trials

Saint Joseph, Missouri, 64506

Hassman Research Institute, Berlin, New Jersey

Status

Active, not recruiting

Address

Hassman Research Institute

Berlin, New Jersey, 08009

East Windsor, New Jersey

Status

Active, not recruiting

Address

Psoriasis Treatment Center of Central New Jersey

East Windsor, New Jersey, 08520

Bayside Dermatology Center, Bayside, New York

Status

Active, not recruiting

Address

Bayside Dermatology Center

Bayside, New York, 11360

Dermatology Consulting Services, PLLC, High Point, North Carolina

Status

Active, not recruiting

Address

Dermatology Consulting Services, PLLC

High Point, North Carolina, 27262

M3 Wake Research, Inc., Raleigh, North Carolina

Status

Active, not recruiting

Address

M3 Wake Research, Inc.

Raleigh, North Carolina, 27612

Tulsa, Oklahoma

Status

Recruiting

Address

Vital Prospects Clinical Research Institute, PC

Tulsa, Oklahoma, 74136

Health Concepts, Rapid City, South Dakota

Status

Recruiting

Address

Health Concepts

Rapid City, South Dakota, 57702

Rivergate Dermatology Clinical Research, Goodlettsville, Tennessee

Status

Active, not recruiting

Address

Rivergate Dermatology Clinical Research

Goodlettsville, Tennessee, 37072

Austin, Texas

Status

Active, not recruiting

Address

Austin Institute for Clinical Research, Inc.

Austin, Texas, 78705

studies in Dermatology, LLC, Cypress, Texas

Status

Recruiting

Address

studies in Dermatology, LLC

Cypress, Texas, 77433

Center for Clinical Studies, Houston, Texas

Status

Recruiting

Address

Center for Clinical Studies

Houston, Texas, 77004

Texas Dermatology and Laser Specialists, San Antonio, Texas

Status

Active, not recruiting

Address

Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218

Center for Clinical Studies, Webster, Texas

Status

Recruiting

Address

Center for Clinical Studies

Webster, Texas, 77598

Summit Clinical Research, LLC, Franklin, Virginia

Status

Active, not recruiting

Address

Summit Clinical Research, LLC

Franklin, Virginia, 23851

Norfolk, Virginia

Status

Active, not recruiting

Address

Virginia Dermatology and Skin Cancer Center

Norfolk, Virginia, 23502

International Sites

Veracity Clinical Research Pty Ltd, Woolloongabba, Queensland, Australia

Status

Active, not recruiting

Address

Veracity Clinical Research Pty Ltd

Woolloongabba, Queensland, 4102

Emeritus Research, Camberwell, Victoria, Australia

Status

Active, not recruiting

Address

Emeritus Research

Camberwell, Victoria, 3124

Sinclair Dermatology, East Melbourne, Victoria, Australia

Status

Active, not recruiting

Address

Sinclair Dermatology

East Melbourne, Victoria, 3002

Cabrini Hospital, Malvern, Victoria, Australia

Status

Active, not recruiting

Address

Cabrini Hospital

Malvern, Victoria, 3144

Sofia, Bulgaria

Status

Active, not recruiting

Address

Center for Skin and Venereal Diseases EOOD - Sofia

Sofia, , 1404

DCC Alexandrovska, Sofia, Bulgaria

Status

Active, not recruiting

Address

DCC Alexandrovska

Sofia, , 1431

Sofia, Bulgaria

Status

Active, not recruiting

Address

Diagnostic Consultative Center - Fokus-5 - Medical Establishment for Outpatient Care OOD

Sofia, , 1463

Dermatological Clinic Sofia, Sofia, Bulgaria

Status

Active, not recruiting

Address

Dermatological Clinic Sofia

Sofia, , 1756

Wiseman Dermatology Research Inc., Winnipeg, Manitoba, Canada

Status

Active, not recruiting

Address

Wiseman Dermatology Research Inc.

Winnipeg, Manitoba, R3M 3Z4

SKiN Health, Cobourg, Ontario, Canada

Status

Active, not recruiting

Address

SKiN Health

Cobourg, Ontario, K9A 4J9

Innovaderm Research Inc., Montreal, Quebec, Canada

Status

Active, not recruiting

Address

Innovaderm Research Inc.

Montreal, Quebec, H2X 2V1

Diex Recherche Sherbrooke Inc., Sherbrooke, Quebec, Canada

Status

Active, not recruiting

Address

Diex Recherche Sherbrooke Inc.

Sherbrooke, Quebec, J1L 0H8

Gentofte Hospital, Hellerup, Denmark

Status

Active, not recruiting

Address

Gentofte Hospital

Hellerup, , 2900

Fachklinik Bad Bentheim, Bad Bentheim, Germany

Status

Active, not recruiting

Address

Fachklinik Bad Bentheim

Bad Bentheim, , 48455

Emovis GmbH, Berlin, Germany

Status

Active, not recruiting

Address

Emovis GmbH

Berlin, , 10629

Rothhaar Studien GmbH, Berlin, Germany

Status

Active, not recruiting

Address

Rothhaar Studien GmbH

Berlin, , 10783

Berlin, Germany

Status

Active, not recruiting

Address

ISA - Interdisciplinary Study Association GmbH

Berlin, , 10789

Klinikum Bielefeld gem.GmbH, Bielefeld, Germany

Status

Active, not recruiting

Address

Klinikum Bielefeld gem.GmbH

Bielefeld, , 33647

Dresden, Germany

Status

Active, not recruiting

Address

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden

Dresden, , 01307

MENSINGDERMA research GmbH, Hamburg, Germany

Status

Terminated

Address

MENSINGDERMA research GmbH

Hamburg, , 22391

MVZ Alstermed GmbH, Hamburg, Germany

Status

Terminated

Address

MVZ Alstermed GmbH

Hamburg, , 22391

Dermatologische Gemeinschaftspraxis, Mahlow, Germany

Status

Active, not recruiting

Address

Dermatologische Gemeinschaftspraxis

Mahlow, , 15831

Klinische Forschung Schwerin GmbH, Schwerin, Germany

Status

Active, not recruiting

Address

Klinische Forschung Schwerin GmbH

Schwerin, , 19055

Budapest, Hungary

Status

Active, not recruiting

Address

Semmelweis Egyetem Altalanos Orvostudomanyi Kar

Budapest, , 1085

Debreceni Egyetem Klinikai Kozpont, Debrecen, Hungary

Status

Active, not recruiting

Address

Debreceni Egyetem Klinikai Kozpont

Debrecen, , 4032

Kecskemet, Hungary

Status

Active, not recruiting

Address

Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza

Kecskemet, , 6000

Szeged, Hungary

Status

Active, not recruiting

Address

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, , 6720

Kitago Dermatology Clinic, Sapporo-shi, Hokkaido, Japan

Status

Active, not recruiting

Address

Kitago Dermatology Clinic

Sapporo-shi, Hokkaido, 003-0833

Nakatsuhifuka Clinic, Kita-ku, Osaka-shi, Osaka, Japan

Status

Active, not recruiting

Address

Nakatsuhifuka Clinic

Kita-ku, Osaka-shi, Osaka, 531-0072

Parkside Hiroo Ladies Clinic, Minato-ku, Tokyo, Japan

Status

Active, not recruiting

Address

Parkside Hiroo Ladies Clinic

Minato-ku, Tokyo, 106-0047

Tanpopo Skin Clinic, Ota Ku, Tokyo, Japan

Status

Active, not recruiting

Address

Tanpopo Skin Clinic

Ota Ku, Tokyo, 143-0023

Samoncho Dermatological Clinic, Shinjuku-ku, Tokyo, Japan

Status

Active, not recruiting

Address

Samoncho Dermatological Clinic

Shinjuku-ku, Tokyo, 160-0017

Tachikawa, Tokyo, Japan

Status

Active, not recruiting

Address

Medical Corporation Jitai-kai Tachikawa Dermatology Clinic

Tachikawa, Tokyo, 190-0023

Riga 1st Hospital, Riga, Latvia

Status

Active, not recruiting

Address

Riga 1st Hospital

Riga, , LV-1001

Riga, Latvia

Status

Active, not recruiting

Address

Aesthetic dermatology clinic of Prof. J. Kisis

Riga, , LV-1003

Health and Aesthetics Ltd, Riga, Latvia

Status

Active, not recruiting

Address

Health and Aesthetics Ltd

Riga, , LV-1009

Outpatient Clinic of Ventspils, Ventspils, Latvia

Status

Active, not recruiting

Address

Outpatient Clinic of Ventspils

Ventspils, , LV3601

Bialystok, Poland

Status

Active, not recruiting

Address

Zdrowie Osteo-Medic s.c. LiA Racewicz, AiJ Supronik

Bialystok, , 15-351

Nasz Lekarz Przychodnie Medyczne, Torun, Poland

Status

Active, not recruiting

Address

Nasz Lekarz Przychodnie Medyczne

Torun, , 87-100

MTZ Clinical Research Sp. z o.o, Warszawa, Poland

Status

Active, not recruiting

Address

MTZ Clinical Research Sp. z o.o

Warszawa, , 02-106

Wroclaw, Poland

Status

Active, not recruiting

Address

WroMedica I. Bielicka, A. Strzalkowska s.c.

Wroclaw, , 51-685

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