Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In Psoriasis
Study Purpose
This is a Phase 2b, randomized, double blind, vehicle controlled, parallel group, multicenter study in participants with mild to moderate plaque psoriasis. The duration of study participation will be approximately 22 weeks, including up to a 6 week screening period, 12 week treatment period, and approximately 4 week follow up period. Approximately 280 participants are planned to be randomized into the study.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years - 75 Years |
Gender | All |
Inclusion Criteria:
- - plaque psoriasis for 6 months.
- - PGA score mild or moderate.
- - body surface area (BSA) 2-15%
Exclusion Criteria:
- other skin conditions that would interfere with the evaluation of psoriasis.
- - history of herpes zoster or simplex.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03850483 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Pfizer |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Pfizer CT.gov Call Center |
Principal Investigator Affiliation | Pfizer |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Australia, Bulgaria, Canada, Denmark, Germany, Hungary, Japan, Latvia, Poland, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Psoriasis |
Study Website: | View Trial Website |
Arms
Placebo Comparator: Vehicle cream QD
Vehicle cream applied once daily (QD)
Experimental: PF-06700841 0.1% cream QD
PF-06700841 0.1% cream applied once daily (QD)
Experimental: PF-06700841 0.3% cream QD
PF-06700841 0.3% cream applied once daily (QD)
Experimental: PF-06700841 1% cream QD
PF-06700841 1% cream applied once daily (QD)
Experimental: PF-06700841 3% cream QD
PF-06700841 3% cream applied once daily (QD)
Experimental: PF-06700841 0.3% cream BID
PF-06700841 0.3% cream applied twice daily (BID)
Experimental: PF-06700841 1% cream BID
PF-06700841 1% cream applied twice daily (BID)
Placebo Comparator: Vehicle cream BID
Vehicle cream applied twice daily (BID)
Experimental: PF-06700841 3% cream BID
PF-06700841 3% cream applied twice daily (BID)
Interventions
Drug: - PF-06700841
PF-06700841 topical cream
Drug: - Vehicle (Placebo)
Vehicle topical cream
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Active, not recruiting
Address
Center for Dermatology and Plastic Surgery/CCT
Scottsdale, Arizona, 85260
Status
Active, not recruiting
Address
Center for Dermatology and Plastic Surgery
Scottsdale, Arizona, 85260
Status
Active, not recruiting
Address
Burke Pharmaceutical Research
Hot Springs, Arkansas, 71913
Status
Active, not recruiting
Address
Anaheim Clinical Trials, LLC
Anaheim, California, 92801
Status
Active, not recruiting
Address
California Skin Institute
Anaheim, California, 92801
Status
Active, not recruiting
Address
California Dermatology & Clinical Research Institute
Encinitas, California, 92024
Status
Active, not recruiting
Address
First OC Dermatology
Fountain Valley, California, 92708
Status
Active, not recruiting
Address
Clinical Science Institute
Santa Monica, California, 90404
Status
Active, not recruiting
Address
New England Research Associates, LLC
Bridgeport, Connecticut, 06606
Status
Active, not recruiting
Address
Dermatology Physicians of Connecticut
Shelton, Connecticut, 06848
Status
Active, not recruiting
Address
Olympian Clinical Research
Clearwater, Florida, 33756
Status
Active, not recruiting
Address
Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, 32720
Status
Active, not recruiting
Address
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
Status
Active, not recruiting
Address
Renstar Medical Research
Ocala, Florida, 34470
Status
Active, not recruiting
Address
MidState Skin Institute
Ocala, Florida, 34471
Status
Active, not recruiting
Address
Renstar Medical Research
Ocala, Florida, 34471
Status
Active, not recruiting
Address
Park Avenue Dermatology, PA
Orange Park, Florida, 32073
Status
Active, not recruiting
Address
ForCare Clinical Research
Tampa, Florida, 33613
Status
Active, not recruiting
Address
Dundee Dermatology
West Dundee, Illinois, 60118
Status
Active, not recruiting
Address
DS Research
Clarksville, Indiana, 47129
Status
Active, not recruiting
Address
DS Research
Louisville, Kentucky, 40241
Status
Active, not recruiting
Address
Meridian Clinical Research, LLC
Baton Rouge, Louisiana, 70808
Status
Active, not recruiting
Address
MediSearch Clinical Trials
Saint Joseph, Missouri, 64506
Status
Active, not recruiting
Address
Hassman Research Institute
Berlin, New Jersey, 08009
Status
Active, not recruiting
Address
Psoriasis Treatment Center of Central New Jersey
East Windsor, New Jersey, 08520
Status
Active, not recruiting
Address
Bayside Dermatology Center
Bayside, New York, 11360
Status
Active, not recruiting
Address
Dermatology Consulting Services, PLLC
High Point, North Carolina, 27262
Status
Active, not recruiting
Address
M3 Wake Research, Inc.
Raleigh, North Carolina, 27612
Status
Recruiting
Address
Vital Prospects Clinical Research Institute, PC
Tulsa, Oklahoma, 74136
Status
Recruiting
Address
Health Concepts
Rapid City, South Dakota, 57702
Status
Active, not recruiting
Address
Rivergate Dermatology Clinical Research
Goodlettsville, Tennessee, 37072
Status
Active, not recruiting
Address
Austin Institute for Clinical Research, Inc.
Austin, Texas, 78705
Status
Recruiting
Address
studies in Dermatology, LLC
Cypress, Texas, 77433
Status
Recruiting
Address
Center for Clinical Studies
Houston, Texas, 77004
Status
Active, not recruiting
Address
Texas Dermatology and Laser Specialists
San Antonio, Texas, 78218
Status
Recruiting
Address
Center for Clinical Studies
Webster, Texas, 77598
Status
Active, not recruiting
Address
Summit Clinical Research, LLC
Franklin, Virginia, 23851
Status
Active, not recruiting
Address
Virginia Dermatology and Skin Cancer Center
Norfolk, Virginia, 23502
International Sites
Status
Active, not recruiting
Address
Veracity Clinical Research Pty Ltd
Woolloongabba, Queensland, 4102
Status
Active, not recruiting
Address
Emeritus Research
Camberwell, Victoria, 3124
Status
Active, not recruiting
Address
Sinclair Dermatology
East Melbourne, Victoria, 3002
Status
Active, not recruiting
Address
Cabrini Hospital
Malvern, Victoria, 3144
Status
Active, not recruiting
Address
Center for Skin and Venereal Diseases EOOD - Sofia
Sofia, , 1404
Status
Active, not recruiting
Address
DCC Alexandrovska
Sofia, , 1431
Status
Active, not recruiting
Address
Diagnostic Consultative Center - Fokus-5 - Medical Establishment for Outpatient Care OOD
Sofia, , 1463
Status
Active, not recruiting
Address
Dermatological Clinic Sofia
Sofia, , 1756
Status
Active, not recruiting
Address
Wiseman Dermatology Research Inc.
Winnipeg, Manitoba, R3M 3Z4
Status
Active, not recruiting
Address
SKiN Health
Cobourg, Ontario, K9A 4J9
Status
Active, not recruiting
Address
Innovaderm Research Inc.
Montreal, Quebec, H2X 2V1
Status
Active, not recruiting
Address
Diex Recherche Sherbrooke Inc.
Sherbrooke, Quebec, J1L 0H8
Status
Active, not recruiting
Address
Gentofte Hospital
Hellerup, , 2900
Status
Active, not recruiting
Address
Fachklinik Bad Bentheim
Bad Bentheim, , 48455
Status
Active, not recruiting
Address
Emovis GmbH
Berlin, , 10629
Status
Active, not recruiting
Address
Rothhaar Studien GmbH
Berlin, , 10783
Status
Active, not recruiting
Address
ISA - Interdisciplinary Study Association GmbH
Berlin, , 10789
Status
Active, not recruiting
Address
Klinikum Bielefeld gem.GmbH
Bielefeld, , 33647
Status
Active, not recruiting
Address
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
Dresden, , 01307
Status
Terminated
Address
MENSINGDERMA research GmbH
Hamburg, , 22391
Status
Terminated
Address
MVZ Alstermed GmbH
Hamburg, , 22391
Status
Active, not recruiting
Address
Dermatologische Gemeinschaftspraxis
Mahlow, , 15831
Status
Active, not recruiting
Address
Klinische Forschung Schwerin GmbH
Schwerin, , 19055
Status
Active, not recruiting
Address
Semmelweis Egyetem Altalanos Orvostudomanyi Kar
Budapest, , 1085
Status
Active, not recruiting
Address
Debreceni Egyetem Klinikai Kozpont
Debrecen, , 4032
Status
Active, not recruiting
Address
Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza
Kecskemet, , 6000
Status
Active, not recruiting
Address
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, , 6720
Status
Active, not recruiting
Address
Kitago Dermatology Clinic
Sapporo-shi, Hokkaido, 003-0833
Status
Active, not recruiting
Address
Nakatsuhifuka Clinic
Kita-ku, Osaka-shi, Osaka, 531-0072
Status
Active, not recruiting
Address
Parkside Hiroo Ladies Clinic
Minato-ku, Tokyo, 106-0047
Status
Active, not recruiting
Address
Tanpopo Skin Clinic
Ota Ku, Tokyo, 143-0023
Status
Active, not recruiting
Address
Samoncho Dermatological Clinic
Shinjuku-ku, Tokyo, 160-0017
Status
Active, not recruiting
Address
Medical Corporation Jitai-kai Tachikawa Dermatology Clinic
Tachikawa, Tokyo, 190-0023
Status
Active, not recruiting
Address
Riga 1st Hospital
Riga, , LV-1001
Status
Active, not recruiting
Address
Aesthetic dermatology clinic of Prof. J. Kisis
Riga, , LV-1003
Status
Active, not recruiting
Address
Health and Aesthetics Ltd
Riga, , LV-1009
Status
Active, not recruiting
Address
Outpatient Clinic of Ventspils
Ventspils, , LV3601
Status
Active, not recruiting
Address
Zdrowie Osteo-Medic s.c. LiA Racewicz, AiJ Supronik
Bialystok, , 15-351
Status
Active, not recruiting
Address
Nasz Lekarz Przychodnie Medyczne
Torun, , 87-100
Status
Active, not recruiting
Address
MTZ Clinical Research Sp. z o.o
Warszawa, , 02-106
Status
Active, not recruiting
Address
WroMedica I. Bielicka, A. Strzalkowska s.c.
Wroclaw, , 51-685