A Study of LY3471851 in Participants With Psoriasis

Study Purpose

The main purpose of this study is to learn more about the safety and side effects of LY3471851 when given by injection just under the skin to participants with psoriasis. The study will last up to 48 weeks and may include up to 23 visits to the study center.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 70 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Have a confirmed diagnosis of psoriasis for at least 6 months - Have active psoriasis plaques according to study- specific criteria - Be willing and able to undergo skin biopsies

Exclusion Criteria:

- Have received certain topical medications for psoriasis within 14 days prior to baseline - Have received certain systemic medications for psoriasis within 4 weeks prior to baseline - Have received LY3471851 previously

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04119557
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 1
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Eli Lilly and Company
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Principal Investigator Affiliation Eli Lilly and Company
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

IndustryIndustry
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Psoriasis
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: LY3471851

LY3471851 administered subcutaneously (SC)

Placebo Comparator: Placebo

Placebo administered SC

Interventions

Drug: - LY3471851

Administered SC

Drug: - Placebo

Administered SC

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Arkansas Research Trials, LLC, North Little Rock, Arkansas

Status

Not yet recruiting

Address

Arkansas Research Trials, LLC

North Little Rock, Arkansas, 72117

Encinitas, California

Status

Recruiting

Address

California Dermatology & Clinical Research Institute

Encinitas, California, 92024

First OC Dermatology, Fountain Valley, California

Status

Not yet recruiting

Address

First OC Dermatology

Fountain Valley, California, 92708

Therapeutics Clinical Research, San Diego, California

Status

Recruiting

Address

Therapeutics Clinical Research

San Diego, California, 92123

Coral Gables, Florida

Status

Active, not recruiting

Address

Florida Academic Centers Research and Education, LLC

Coral Gables, Florida, 33134

Miami Dermatology and Laser Research, Miami, Florida

Status

Not yet recruiting

Address

Miami Dermatology and Laser Research

Miami, Florida, 33173

ForCare Clinical Research, Tampa, Florida

Status

Recruiting

Address

ForCare Clinical Research

Tampa, Florida, 33613-1244

Medical Dermatology Specialists, Sandy Springs, Georgia

Status

Recruiting

Address

Medical Dermatology Specialists

Sandy Springs, Georgia, 30328

Indianapolis, Indiana

Status

Recruiting

Address

Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250

Skin Sciences, Louisville, Kentucky

Status

Recruiting

Address

Skin Sciences

Louisville, Kentucky, 40217

Forefront Research, Louisville, Kentucky

Status

Recruiting

Address

Forefront Research

Louisville, Kentucky, 40241

Chesterfield, Michigan

Status

Not yet recruiting

Address

Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, 48047

Derm Center, Troy, Michigan

Status

Recruiting

Address

Derm Center

Troy, Michigan, 48084

Central Dermatology PC, Saint Louis, Missouri

Status

Recruiting

Address

Central Dermatology PC

Saint Louis, Missouri, 63117

ActivMed Practices and Research, Portsmouth, New Hampshire

Status

Recruiting

Address

ActivMed Practices and Research

Portsmouth, New Hampshire, 03801

Remington-Davis, Inc, Columbus, Ohio

Status

Recruiting

Address

Remington-Davis, Inc

Columbus, Ohio, 43215

Unity Clinical Research, Oklahoma City, Oklahoma

Status

Recruiting

Address

Unity Clinical Research

Oklahoma City, Oklahoma, 73118

Paddington Testing Company Inc, Philadelphia, Pennsylvania

Status

Recruiting

Address

Paddington Testing Company Inc

Philadelphia, Pennsylvania, 19103

DermDox Centers for Dermatology, Sugarloaf, Pennsylvania

Status

Recruiting

Address

DermDox Centers for Dermatology

Sugarloaf, Pennsylvania, 18249

Studies in Dermatology, LLC, Cypress, Texas

Status

Not yet recruiting

Address

Studies in Dermatology, LLC

Cypress, Texas, 77433

Rodgers Dermatology, Frisco, Texas

Status

Recruiting

Address

Rodgers Dermatology

Frisco, Texas, 75034

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