A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis

Study Purpose

This is a study in adolescents and adults with Generalized Pustular Psoriasis (GPP). People between 12 and 75 years old can take part in the study. The study is open to people who had GPP flare-ups in the past but whose skin is clear or almost clear when they join the study. The purpose of the study is to test 3 different doses of a medicine called spesolimab and to see whether it helps to prevent GPP flare-ups. Participants are put into 4 groups by chance. Three groups get different doses of spesolimab. The fourth group gets a placebo. Placebo looks like spesolimab but does not contain any medicine. Spesolimab and placebo are given as an injection under the skin. Participants are in the study for about 1 year and 4 months. During this time, they visit the study site about 15 times. For the first 11 months, participants get spesolimab or placebo injections every month. At the study visits, the doctors check participants' skin for signs of a new GPP flare-up. The doctors also check the general health of the participants. If a participant has a GPP flare-up during the study, more visits may be necessary. In case of a flare-up, participants get a dose of spesolimab as an infusion into a vein.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 12 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Patients with a known and documented history of GPP per ERASPEN criteria (see Section 3.3.
1) regardless of IL36RN mutation status, with at least 2 presentations of moderate to severe GPP flares with fresh pustulation (new appearance or worsening) in the past.
  • - Patients with a GPPGA score of 0 or 1 at screening and randomization.
  • - Patients who are not on concomitant GPP treatment at time of randomization (V2) must have had at least two presentations of moderate to severe GPP flare in the past year, at least one of which had evidence of either fever and/or elevated CRP and/or elevated WBC, and/or asthenia and/or myalgia.
  • - Patients who are not on concomitant GPP treatment at time of randomization (V2) but who were on concomitant GPP treatment until shortly before randomization (V2) (≤ 12 weeks before randomization), these patients must have a history of flaring while on concomitant treatment for GPP or in case of dose reduction or discontinuation of their concomitant medication.
  • - Patients who are on concomitant treatment regimen with retinoids and/or methotrexate and/or cyclosporine must stop at the day of randomization (V2).
These patients must have a history of flaring while on concomitant treatment for GPP or in case of dose reduction or discontinuation of these concomitant medications.
  • - Male or female patients, aged 12 to 75 years at screening.
For all patients, a minimum weight of 40 kg is required.
  • - Signed and dated written informed consent and assent in accordance with ICH-GCP and local legislation prior to admission in the trial.
  • - Women of childbearing potential (WOCBP)1 must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly.
A list of contraception methods meeting these criteria is provided in the CTP as well as in the patient, parent(s) (or patient's legal guardian) information.

Exclusion Criteria:

1. Patients with SAPHO (Synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. 2. Patients with primary erythrodermic psoriasis vulgaris. 3. Severe, progressive, or uncontrolled hepatic disease, defined as >3-fold Upper Limit of Normal (ULN) elevation in Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) or alkaline phosphatase, or >2-fold ULN elevation in total bilirubin. 4. Treatment with: 1. Any restricted medication as specified in the CTP, or any drug considered likely to interfere with the safe conduct of the study, as assessed by the investigator. 2. Any prior exposure to BI 655130 or another IL36R inhibitor biologic. 5. Increased risk of infectious complications (e.g. recent pyogenic infection, any congenital or acquired immunodeficiency (e.g. HIV), past organ or stem cell transplantation), as assessed by the investigator. 6. Relevant chronic or acute infections including active tuberculosis, human immunodeficiency virus (HIV) infection or viral hepatitis at the time of randomization. A patient can be re-screened if the patient was treated and is cured from the acute infection. 7. Active or Latent Tuberculosis (TB):
  • - Patients with active tuberculosis should be excluded.
  • - Patients with a positive QuantiFERON® (or if applicable, T-Spot®) TB test during screening are excluded, unless the patient had previous diagnosis of active or latent TB and has completed appropriate treatment per the discretion of the local investigator within the last 3 years and at the latest at the time of screening (i.e. 2 to 4 weeks before study drug administration); patients may be re-screened once to meet this criterion) - Patients with suspected false positive or indeterminate QuantiFERON® (or if applicable, T-Spot®) TB result may be re-tested once.
  • - If QuantiFERON® (or if applicable, T-Spot®) TB testing is not available or provides indeterminate results after repeat testing, a tuberculin skin test (TST) can be performed: A TST reaction of ≥10mm (≥5mm if receiving ≥15mg/d prednisone or its equivalent) is considered positive.
8. History of allergy/hypersensitivity to the systemically administered trial medication agent or its excipients. Further exclusion criteria apply.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04399837
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Boehringer Ingelheim
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Australia, Belgium, Bulgaria, Chile, China, Colombia, France, Georgia, Germany, Greece, Italy, Japan, Korea, Republic of, Malaysia, Mexico, Netherlands, Philippines, Poland, Russian Federation, Singapore, South Africa, Spain, Taiwan, Thailand, Tunisia, Turkey, United States, Vietnam
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Generalized Pustular Psoriasis
Study Website: View Trial Website
Arms & Interventions

Arms

Experimental: Spesolimab, treatment arm 1

Experimental: Spesolimab, treatment arm 2

Experimental: Spesolimab, treatment arm 3

Placebo Comparator: Placebo

Interventions

Drug: - Spesolimab

Solution for injection

Drug: - Placebo

Solution for injection

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham, Alabama

Status

Recruiting

Address

Total Skin and Beauty Dermatology Center, PC

Birmingham, Alabama, 35205

Site Contact

James Krell

[email protected]

+001 (205) 933-0987

Fremont, California

Status

Recruiting

Address

Center for Dermatology Clinical Research, Inc.

Fremont, California, 94538

Site Contact

Sunil Dhawan

[email protected]

+001 (510) 797-0140-x3

Therapeutics Clinical Research, San Diego, California

Status

Recruiting

Address

Therapeutics Clinical Research

San Diego, California, 92123

Site Contact

Neal Bhatia

[email protected]

+001 (858) 571-6800

Clinical Science Institute, Santa Monica, California

Status

Recruiting

Address

Clinical Science Institute

Santa Monica, California, 90404

Site Contact

Paul Yamauchi

[email protected]

+001 (310) 828-8887

Advanced DermCare, Danbury, Connecticut

Status

Recruiting

Address

Advanced DermCare

Danbury, Connecticut, 06811

Site Contact

Graeme Lipper

[email protected]

+001 (203) 616-2710

University of Miami, Miami, Florida

Status

Recruiting

Address

University of Miami

Miami, Florida, 33125

Site Contact

Anna Nichols

[email protected]

+001 (305) 243-0851

University of South Florida, Tampa, Florida

Status

Recruiting

Address

University of South Florida

Tampa, Florida, 33612

Site Contact

James Grichnik

[email protected]

1-800-243-0127

Oakland Hills Dermatology, Auburn Hills, Michigan

Status

Recruiting

Address

Oakland Hills Dermatology

Auburn Hills, Michigan, 48326

Site Contact

Christofer Buatti

[email protected]

+001 (248) 858-2255

Great Lakes Research Group, Inc., Bay City, Michigan

Status

Recruiting

Address

Great Lakes Research Group, Inc.

Bay City, Michigan, 48706

Site Contact

Brent Boyce

[email protected]

+001 (989) 895-9100

Washington University School of Medicine, Saint Louis, Missouri

Status

Recruiting

Address

Washington University School of Medicine

Saint Louis, Missouri, 63108

Site Contact

Milan Anadkat

[email protected]edu

+001 (314) 362-9859

Dermatology Associates of Mid-Ohio, Marion, Ohio

Status

Recruiting

Address

Dermatology Associates of Mid-Ohio

Marion, Ohio, 43302

Site Contact

George Drew

[email protected]

+001 (740) 244-8550

International Sites

Buenos Aires Skin S.A., Caba, Argentina

Status

Recruiting

Address

Buenos Aires Skin S.A.

Caba, , C1055AA0

Site Contact

Pablo González

[email protected]

+54 11 5219-0541/42/43

Halitus Instituto Médico, Caba, Argentina

Status

Recruiting

Address

Halitus Instituto Médico

Caba, , C1122AAF

Site Contact

Ignacio Dei-Cas

[email protected]

+54 11 5273200

Hospital Italiano de Buenos Aires, Caba, Argentina

Status

Recruiting

Address

Hospital Italiano de Buenos Aires

Caba, , C1199ABD

Site Contact

María Galimberti

[email protected]

+54 11 4959 0200 ext 9518

Caba, Argentina

Status

Recruiting

Address

Psoriahue Medicina Interdisciplinaria S.R.L

Caba, , C1425DKG

Site Contact

Gabriel Magariños

[email protected]

+54 11 48238755

Sourigues, Berazategui, Argentina

Status

Recruiting

Address

Asociación de Fomento y Sala de primeros auxilios" Alberto Mignaburu"

Sourigues, Berazategui, , B1837AVT

Site Contact

Gabriela Nasuti

[email protected]

+54 11 42235050

Westmead Hospital, Westmead, New South Wales, Australia

Status

Recruiting

Address

Westmead Hospital

Westmead, New South Wales, 2145

Site Contact

Pablo Fernandez-Penas

[email protected]

61 2 8890 9767

Royal Melbourne Hospital, Parkville, Victoria, Australia

Status

Recruiting

Address

Royal Melbourne Hospital

Parkville, Victoria, 3050

Site Contact

Johannes Kern

[email protected]

61 3 9342 4531

Brussels - UNIV Saint-Luc, Bruxelles, Belgium

Status

Recruiting

Address

Brussels - UNIV Saint-Luc

Bruxelles, , 1200

Site Contact

Pierre-Dominique Ghislain

[email protected]

+32 (0)2 764 14 72

Liège, Belgium

Status

Recruiting

Address

Centre Hospitalier Universitaire de Liège

Liège, , 4000

Site Contact

Arjen Nikkels

[email protected]

+32 (0)4 366 72 32

Sofia, Bulgaria

Status

Recruiting

Address

University Multiprofile Hospital 'Alexandrovska', Sofia

Sofia, , 1431

Site Contact

Petyo Brezoev

[email protected]

+359-2-9230 720

Clínica Dermacross S.A., Vitacura, Chile

Status

Recruiting

Address

Clínica Dermacross S.A.

Vitacura, , 7640881

Site Contact

Claudia de la Cruz Fernández

[email protected]

+562 2 954 0251

West China Hospital, Chengdu, China

Status

Recruiting

Address

West China Hospital

Chengdu, , 610041

Site Contact

Xian Jiang

[email protected]

18980601693

Guangzhou, China

Status

Recruiting

Address

Sun yet-sen Memorial Hospital, Sun yet-sen Univesity

Guangzhou, , 510288

Site Contact

Qing Guo

[email protected]

18922182868

Hangzhou, China

Status

Recruiting

Address

2nd Affiliated Hosp Zhejiang University College of Medical

Hangzhou, , 310009

Site Contact

Min Zheng

[email protected]

13906520296

Shanghai Skin Disease Hospital, Shanghai, China

Status

Recruiting

Address

Shanghai Skin Disease Hospital

Shanghai, , 200000

Site Contact

Yangfeng Ding

[email protected]

18017336636

Huashan Hospital, Fudan University, Shanghai, China

Status

Recruiting

Address

Huashan Hospital, Fudan University

Shanghai, , 200040

Site Contact

Jinhua Xu

[email protected]

13818978539

Shenyang, China

Status

Recruiting

Address

The First Hospital of Chinese Medical University

Shenyang, , 110001

Site Contact

Xinghua Gao

[email protected]

13940152467

Tianjin, China

Status

Recruiting

Address

Affiliated Hospital of Tianjin institute of Chinese medicine

Tianjin, , 300120

Site Contact

Litao Zhang

[email protected]

18602228122

Tianjin, China

Status

Recruiting

Address

Tianjin Medical University General Hospital

Tianjin, , 30052

Site Contact

Quanzhong Liu

[email protected]

+8613662162889

Xi'An, China

Status

Recruiting

Address

Second Affiliated Hospital of Xi'an JiaoTong University

Xi'An, , 710004

Site Contact

Songmei Geng

[email protected]

13060423612

Bogota, Colombia

Status

Recruiting

Address

CIREEM SAS (Centro de Investigación en Reumatología y Especialidades Médicas)

Bogota, , 110231

Site Contact

David Castillo Molina

[email protected]

+57 1 6018862

HOP Saint-André, Bordeaux, France

Status

Recruiting

Address

HOP Saint-André

Bordeaux, , 33000

Site Contact

Marie Beylot-Barry

[email protected]

+33 (0)5 57 82 25 00

HOP Claude Huriez, Lille, France

Status

Recruiting

Address

HOP Claude Huriez

Lille, , 59037

Site Contact

Delphine Staumont

[email protected]

+33 (0)3 20 44 41 93

HOP l'Archet, Nice, France

Status

Recruiting

Address

HOP l'Archet

Nice, , 06200

Site Contact

Thierry Passeron

[email protected]

+33 (0)4 92 03 92 24

HOP Saint-Louis, Paris, France

Status

Recruiting

Address

HOP Saint-Louis

Paris, , 75010

Site Contact

Hervé Bachelez

[email protected]

+33 (0)1 42 49 98 17

HOP Robert Debré, Reims, France

Status

Recruiting

Address

HOP Robert Debré

Reims, , 51092

Site Contact

Manuelle-Anne Viguier

[email protected]

+33 (0)3 26 78 43 43

HOP Larrey, Toulouse, France

Status

Recruiting

Address

HOP Larrey

Toulouse, , 31059

Site Contact

Maria Polina Konstantinou

[email protected]

+33 (0)5 67 77 14 08

Tbilisi, Georgia

Status

Recruiting

Address

LTD Israeli-Georgian Medical Research Clinic "Helsicore"

Tbilisi, , 112

Site Contact

Elguja Beraia

[email protected]

+995 599575283

Universitätsklinikum Aachen, AöR, Aachen, Germany

Status

Recruiting

Address

Universitätsklinikum Aachen, AöR

Aachen, , 52074

Site Contact

Amir Yazdi

[email protected]

+49 (241) 80-0

Fachklinik Bad Bentheim, Bad Bentheim, Germany

Status

Recruiting

Address

Fachklinik Bad Bentheim

Bad Bentheim, , 48455

Site Contact

Athanasios Tsianakas

[email protected]

+49 (5922) 745210

Katholisches Klinikum Bochum gGmbH, Bochum, Germany

Status

Recruiting

Address

Katholisches Klinikum Bochum gGmbH

Bochum, , 44791

Site Contact

Falk Bechara

[email protected]

+49 (234) 509-3415

Universitätsklinikum Bonn AöR, Bonn, Germany

Status

Recruiting

Address

Universitätsklinikum Bonn AöR

Bonn, , 53127

Site Contact

Dagmar Wilsmann-Theis

[email protected]

+49 (228) 28715370

Universitätsklinikum Essen AöR, Essen, Germany

Status

Recruiting

Address

Universitätsklinikum Essen AöR

Essen, , 45147

Site Contact

Wiebke Sondermann

[email protected]

+49 (201) 7230

Universitätsklinikum Frankfurt, Frankfurt am Main, Germany

Status

Recruiting

Address

Universitätsklinikum Frankfurt

Frankfurt am Main, , 60596

Site Contact

Andreas Pinter

[email protected]

+49 (69) 63015418

Göttingen, Germany

Status

Recruiting

Address

Universitätsmedizin Göttingen, Georg-August-Universität

Göttingen, , 37075

Site Contact

Rotraut Mössner

[email protected]

+49 (551) 3966410

Halle, Germany

Status

Recruiting

Address

Martin-Luther-Universität Halle-Wittenberg

Halle, , 06108

Site Contact

Johannes Wohlrab

[email protected]

+49 (345) 5573933

Mainz, Germany

Status

Recruiting

Address

Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, , 55131

Site Contact

Petra Staubach-Renz

[email protected]

+49 (6131) 175732

München, Germany

Status

Recruiting

Address

Klinikum der Universität München - Campus Innenstadt

München, , 80337

Site Contact

Franziska Rueff

[email protected]

+49 (89) 440056661

Universitätsklinikum Münster, Münster, Germany

Status

Recruiting

Address

Universitätsklinikum Münster

Münster, , 48149

Site Contact

Nina Magnolo

[email protected]

+49 (251) 8356558

Klinikum Oldenburg AöR, Oldenburg, Germany

Status

Recruiting

Address

Klinikum Oldenburg AöR

Oldenburg, , 26133

Site Contact

Nikolaos Patsinakidis

[email protected]

+49 (441) 403-0

Universitätsklinikum Tübingen, Tübingen, Germany

Status

Recruiting

Address

Universitätsklinikum Tübingen

Tübingen, , 72076

Site Contact

Matthias Hahn

[email protected]

4970712980816

Universitätsklinikum Würzburg, Würzburg, Germany

Status

Recruiting

Address

Universitätsklinikum Würzburg

Würzburg, , 97080

Site Contact

Andreas Kerstan

[email protected]

+49 (931) 2010

Athens, Greece

Status

Recruiting

Address

Andreas Syggros Hospital of Cutaneous & Venereal Diseases

Athens, , 16121

Site Contact

Dimitrios Rigopoulos

[email protected]

+302107265119

Athens, Greece

Status

Recruiting

Address

Andreas Syggros Hospital of Cutaneous & Venereal Diseases

Athens, , 16121

Site Contact

Vassiliki Chasapi

[email protected]

00302107265191

Thessaloniki, Greece

Status

Recruiting

Address

General Hospital of Thessaloniki "Ippokrateio"

Thessaloniki, , 54643

Site Contact

Dimitrios Ioannides

[email protected]

00306972755124

Policlinico S. Orsola-Malpighi, Bologna, Italy

Status

Recruiting

Address

Policlinico S. Orsola-Malpighi

Bologna, , 40138

Site Contact

Annalisa Patrizi

[email protected]

+39 (051) 6363474

Policlinico San Martino, Genova, Italy

Status

Recruiting

Address

Policlinico San Martino

Genova, , 16132

Site Contact

Aurora PARODI

[email protected]

+39 (010) 5555768

Univ. Cattolica del Sacro Cuore, Roma, Italy

Status

Recruiting

Address

Univ. Cattolica del Sacro Cuore

Roma, , 00168

Site Contact

Ketty Peris

[email protected]

+39 (06) 30154227

Istituto Clinico Humanitas, Rozzano (MI), Italy

Status

Recruiting

Address

Istituto Clinico Humanitas

Rozzano (MI), , 20089

Site Contact

Antonio COSTANZO

[email protected]

+39 (02) 82244061

Nagoya City University Hospital, Aichi, Nagoya, Japan

Status

Recruiting

Address

Nagoya City University Hospital

Aichi, Nagoya, , 467-8602

Site Contact

Akimichi Morita

[email protected]

+81 52 8515511

Kyushu Rosai Hospital, Fukuoka, Kitakyushu, Japan

Status

Recruiting

Address

Kyushu Rosai Hospital

Fukuoka, Kitakyushu, , 800-0296

Site Contact

Manabu Yoshioka

[email protected]

+81 93 4711121

Gifu University Hospital, Gifu, Gifu, Japan

Status

Recruiting

Address

Gifu University Hospital

Gifu, Gifu, , 501-1194

Site Contact

Yoko Mizutani

[email protected]

+81 58 2306000

Asahikawa Medical University Hospital, Hokkaido, Asahikawa, Japan

Status

Recruiting

Address

Asahikawa Medical University Hospital

Hokkaido, Asahikawa, , 078-8510

Site Contact

Masaru Honma

[email protected]

+81 166 652111

Ibaraki, Inashiki-gun, Japan

Status

Recruiting

Address

Tokyo Medical University Ibaraki Medical Center

Ibaraki, Inashiki-gun, , 300-0395

Site Contact

Yasuhiro Kawachi

[email protected]

+81 29 8871161

Iwate Medical University Hospital, Iwate, Morioka, Japan

Status

Recruiting

Address

Iwate Medical University Hospital

Iwate, Morioka, , 020-0023

Site Contact

Daisuke Watabe

[email protected]

+81 19 6137111

Takamatsu Red Cross Hospital, Kagawa, Takamatsu, Japan

Status

Recruiting

Address

Takamatsu Red Cross Hospital

Kagawa, Takamatsu, , 760-0017

Site Contact

Toshihisa Hamada

[email protected]

+81 87 8317101

Mie University Hospital, Mie, Tsu, Japan

Status

Recruiting

Address

Mie University Hospital

Mie, Tsu, , 514-8507

Site Contact

Keiichi Yamanaka

[email protected]

+81 59 2321111

Tohoku University Hospital, Miyagi, Sendai, Japan

Status

Recruiting

Address

Tohoku University Hospital

Miyagi, Sendai, , 980-8574

Site Contact

Kenshi Yamasaki

[email protected]

+81 2 27177000

Kindai University Hospital, Osaka, Osaka-sayama, Japan

Status

Recruiting

Address

Kindai University Hospital

Osaka, Osaka-sayama, , 589-8511

Site Contact

Shigeto Yanagihara

[email protected]

+81 72 3660221

Saitama Medical University Hospital, Saitama, Iruma-gun, Japan

Status

Recruiting

Address

Saitama Medical University Hospital

Saitama, Iruma-gun, , 350-0495

Site Contact

Yuichiro Tsunemi

[email protected]

+81 49 2761111

Tokyo, Hachioji, Japan

Status

Recruiting

Address

Tokyo Medical University Hachioji Medical Center

Tokyo, Hachioji, , 193-0998

Site Contact

Yukihiko Kato

[email protected]

+81 42 6655611

Nihon University Itabashi Hospital, Tokyo, Itabashi, Japan

Status

Recruiting

Address

Nihon University Itabashi Hospital

Tokyo, Itabashi, , 173-8610

Site Contact

Hideki Fujita

[email protected]

+81 3 39728111

The Jikei University Hospital, Tokyo, Minato-ku, Japan

Status

Recruiting

Address

The Jikei University Hospital

Tokyo, Minato-ku, , 105-8471

Site Contact

Yoshinori Umezawa

[email protected]ac.jp

+81 3 34331111

Tokyo Medical University Hospital, Tokyo, Shinjuku-ku, Japan

Status

Recruiting

Address

Tokyo Medical University Hospital

Tokyo, Shinjuku-ku, , 160-0023

Site Contact

Yukari Okubo

[email protected]

+81 3 33426111

Pusan National Univ. Hosp, Busan, Korea, Republic of

Status

Recruiting

Address

Pusan National Univ. Hosp

Busan, , 49241

Site Contact

Byung-Soo Kim

[email protected]

82 2 2072 4916

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Seoul National University Hospital

Seoul, , 03080

Site Contact

Seong-Jin Jo

[email protected]

82 51 240 7338

Severance Hospital, Seoul, Korea, Republic of

Status

Recruiting

Address

Severance Hospital

Seoul, , 03722

Site Contact

Tae-Gyun Kim

[email protected]

82-2-2228-1837

Samsung Medical Center, Seoul, Korea, Republic of

Status

Recruiting

Address

Samsung Medical Center

Seoul, , 06351

Site Contact

Joo-Heung Lee

[email protected]

82 2 3410 2991

Hospital Pulau Pinang, Georgetown Pulau Pinang, Malaysia

Status

Recruiting

Address

Hospital Pulau Pinang

Georgetown Pulau Pinang, , 10990

Site Contact

Wooi Chiang Tan

[email protected]

6042225250

Hospital Sultanah Aminah, Johor Bahru, Malaysia

Status

Recruiting

Address

Hospital Sultanah Aminah

Johor Bahru, , 80100

Site Contact

Siew Eng Choon

[email protected]

+60127162118

Hospital Sultan Ismail, Johor Bahru, Malaysia

Status

Recruiting

Address

Hospital Sultan Ismail

Johor Bahru, , 81100

Site Contact

Latha Selvarajah

[email protected]

+60164539301

Queen Elizabeth Hospital, Kota Kinabalu, Malaysia

Status

Recruiting

Address

Queen Elizabeth Hospital

Kota Kinabalu, , 88586

Site Contact

Michelle Sook Yee Voo

[email protected]

1-800-243-0127

Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

Status

Recruiting

Address

Hospital Kuala Lumpur

Kuala Lumpur, , 50586

Site Contact

Azura Binti Mohd Affandi

[email protected]

60326155555 (1540)

Sarawak General Hospital, Kuching, Sarawak, Malaysia

Status

Recruiting

Address

Sarawak General Hospital

Kuching, Sarawak, , 93586

Site Contact

Pubalan Muniandy

[email protected]

+60128897390

Hospital Pakar Sultanah Fatimah, Muar, Malaysia

Status

Recruiting

Address

Hospital Pakar Sultanah Fatimah

Muar, , 84000

Site Contact

Evelyn Yap

[email protected]

+60176823538

Hospital Raja Permaisuri Bainun, Negeri Perak/Ipoh, Malaysia

Status

Recruiting

Address

Hospital Raja Permaisuri Bainun

Negeri Perak/Ipoh, , 30450

Site Contact

Jyh Jong Tang

[email protected]

6052087494 (7491)

Guadalajara, Mexico

Status

Recruiting

Address

Centro de Investigación de Enfermedades Autoinmunes S.C.

Guadalajara, , 44610

Site Contact

Karla Macias Garcia

[email protected]

+52 33 38231718

Monterrey, Mexico

Status

Recruiting

Address

Hospital Universitario Dr Jose Eleuterio Gonzalez

Monterrey, , 64460

Site Contact

Jorge Ocampo Candiani

[email protected]

+(52-81) 8363-5635

Erasmus Medisch Centrum, Rotterdam, Netherlands

Status

Recruiting

Address

Erasmus Medisch Centrum

Rotterdam, , 3015 GD

Site Contact

Hok B. Thio

[email protected]

+ 31 10 7034580

Southern Philippines Medical Center, Davao City, Philippines

Status

Recruiting

Address

Southern Philippines Medical Center

Davao City, , 8000

Site Contact

Bryan Guevara

[email protected]

+639177250529

Iloilo Doctors Hospital, Iloilo City, Iloilo, Philippines

Status

Recruiting

Address

Iloilo Doctors Hospital

Iloilo City, Iloilo, , 5000

Site Contact

Caroline Arroyo

[email protected]

+639176306808

Makati City, Philippines

Status

Recruiting

Address

Center for Skin Research, Testing and Product Development

Makati City, , 1229

Site Contact

Vermen Rowell

[email protected]

+639178373134

Fryderic Chopin Reg. Clin Hosp.No.1, Rzeszow, Poland

Status

Recruiting

Address

Fryderic Chopin Reg. Clin Hosp.No.1

Rzeszow, , 35055

Site Contact

Adam Reich

[email protected]

+48 17 86 66 170

SBHI Chelyabinsk Reg.Clin.Derma.Dispen., Chelyabinsk, Russian Federation

Status

Recruiting

Address

SBHI Chelyabinsk Reg.Clin.Derma.Dispen.

Chelyabinsk, , 454048

Site Contact

Oleg Ziganshin

[email protected]

+73512320093

LLC "Medical Center Azbuka Zdorovia", Kazan, Russian Federation

Status

Recruiting

Address

LLC "Medical Center Azbuka Zdorovia"

Kazan, , 420111

Site Contact

Bulat Khalilov

[email protected]

+78435280206

Kirov, Russian Federation

Status

Recruiting

Address

FSBEI HE "Kirov State Medical University"

Kirov, , 610035

Site Contact

Sergey Koshkin

[email protected]

+79128254116

Pyatigorsk, Russian Federation

Status

Recruiting

Address

The limited liability company "Clinic USI 4D"

Pyatigorsk, , 357500

Site Contact

Irina Kotelnikova

[email protected]

+79289043230

Saint-Petersburg, Russian Federation

Status

Recruiting

Address

1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.

Saint-Petersburg, , 197022

Site Contact

Evgeny Sokolovsky

[email protected]

+79218646447

Saratov State Med.Univ.n.a.Razumovskogo, Saratov, Russian Federation

Status

Recruiting

Address

Saratov State Med.Univ.n.a.Razumovskogo

Saratov, , 410028

Site Contact

Andrey Bakulev

[email protected]

+78452223855

LLC "Avrora Medfort", St. Petersburg, Russian Federation

Status

Recruiting

Address

LLC "Avrora Medfort"

St. Petersburg, , 194156

Site Contact

Sergey Skrek

[email protected]

+78122737138

EKO-Bezopasnost, St. Petersburg, St. Petersburg, Russian Federation

Status

Recruiting

Address

EKO-Bezopasnost, St. Petersburg

St. Petersburg, , 196143

Site Contact

Olga Parysheva

[email protected]

+78123250305

LLC "New clinic ABIA", St. Petersburg, Russian Federation

Status

Recruiting

Address

LLC "New clinic ABIA"

St. Petersburg, , 197371

Site Contact

Ostap Bondar

[email protected]

+79213822905

Singapore General Hospital, Singapore, Singapore

Status

Recruiting

Address

Singapore General Hospital

Singapore, , 169608

Site Contact

Yi Wei Yeo

[email protected]

+6563266866

Arthritis Clinical Research Trials, Cape Town, South Africa

Status

Recruiting

Address

Arthritis Clinical Research Trials

Cape Town, , 7405

Site Contact

Catherine Spargo

[email protected]

+27 21 5106638

TREAD Research, Cape Town, South Africa

Status

Recruiting

Address

TREAD Research

Cape Town, , 7500

Site Contact

Susanna Kannenberg

[email protected]

+27 21 9317825

University of Cape Town - Lung Institute, Cape Town, South Africa

Status

Recruiting

Address

University of Cape Town - Lung Institute

Cape Town, , 7700

Site Contact

Jonathan Peter

[email protected]

+27 21 4066889

Hospital Santa Creu i Sant Pau, Barcelona, Spain

Status

Recruiting

Address

Hospital Santa Creu i Sant Pau

Barcelona, , 08026

Site Contact

Lluis Puig

[email protected]

+34935565565

Hospital Sant Joan de Déu, Esplugues Del Llobregat, Spain

Status

Recruiting

Address

Hospital Sant Joan de Déu

Esplugues Del Llobregat, , 08950

Site Contact

Asuncion Vicente

[email protected]

+34932532118

Hospital Universitario 12 de Octubre, Madrid, Spain

Status

Recruiting

Address

Hospital Universitario 12 de Octubre

Madrid, , 28041

Site Contact

Raquel Rivera

[email protected]

+34917792261

Hospital Virgen Macarena, Sevilla, Spain

Status

Recruiting

Address

Hospital Virgen Macarena

Sevilla, , 41009

Site Contact

Lara Ferrándiz

[email protected]

+34955008000

Linkou, Taiwan

Status

Recruiting

Address

Chang Gung Medical Foundation (CGMF) - Linkou Bran

Linkou, , 333

Site Contact

Wen-Hung Chung

[email protected]

886 3 328 1200 ext 2215

National Taiwan University Hospital, Taipei, Taiwan

Status

Recruiting

Address

National Taiwan University Hospital

Taipei, , 10002

Site Contact

Tsen Fang Tsai

[email protected]

886 972651561

King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Status

Recruiting

Address

King Chulalongkorn Memorial Hospital

Bangkok, , 10330

Site Contact

Pravit Asawanonda

[email protected]

+66 2 2564246

Institute of Dermatology, Bangkok, Thailand

Status

Recruiting

Address

Institute of Dermatology

Bangkok, , 10400

Site Contact

Bensachee Pattamadilok

[email protected]

+66 2 3545222

Ramathibodi Hospital, Ratchatewi, Bangkok, Thailand

Status

Recruiting

Address

Ramathibodi Hospital

Ratchatewi, Bangkok, , 10400

Site Contact

Natta Rajatanavin

[email protected]

+66 2 2011211

Farhat Hached Hospital, Sousse, Tunisia

Status

Recruiting

Address

Farhat Hached Hospital

Sousse, , 4000

Site Contact

Mohamed Denguezli

[email protected]

00 216 73211183

La Rabta Hospital, Tunis, Tunisia

Status

Recruiting

Address

La Rabta Hospital

Tunis, , 1007

Site Contact

Mourad MOKNI

[email protected]

216 71 566 885

Habib Thameur Hospital, Tunis, Tunisia

Status

Recruiting

Address

Habib Thameur Hospital

Tunis, , 1008

Site Contact

Samy Fennich

[email protected]

1-800-243-0127

Bursa, Turkey

Status

Recruiting

Address

Uludag University Medicine Faculty Departmant of Dermatology

Bursa, , 16059

Site Contact

Emel Bulbul Baskan

[email protected]

00905306448777

Istanbul, Turkey

Status

Recruiting

Address

Bezmi Alem Valide Sultan Vakif Gureba Egitim ve Arastirma Hastanesi

Istanbul, , 34093

Site Contact

Nahide Onsun

[email protected]

00905323925236

Istanbul, Turkey

Status

Recruiting

Address

Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, , 34098

Site Contact

Server Serdaroglu

[email protected]

00905326126453

Marmara Universitesi Tip Fakultesi, Istanbul, Turkey

Status

Recruiting

Address

Marmara Universitesi Tip Fakultesi

Istanbul, , 34460

Site Contact

Tulin Ergun

[email protected]

+905324958545

İstanbul Sultan Abdulhamid Han EAH, Istanbul, Turkey

Status

Recruiting

Address

İstanbul Sultan Abdulhamid Han EAH

Istanbul, , 34668

Site Contact

Sevim Baysak

[email protected]

+90505 817 76 24

Ha Noi, Vietnam

Status

Recruiting

Address

National Hospital of Dermatology and Venereology

Ha Noi, , 10000

Site Contact

Doanh Le

[email protected]

+84 24 38521182

HCMC Hospital of Dermato-Venereology, Ho Chi Minh, Vietnam

Status

Recruiting

Address

HCMC Hospital of Dermato-Venereology

Ho Chi Minh, , 70000

Site Contact

Tuong Pham

[email protected]

+84 28 39301396

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