A Study to Assess the Change in Disease State in Adult Participants Being Treated With Oral Upadacitinib Tablets in Participants With Oligo- or Poly-artIcular Psoriatic Arthritis

Study Purpose

Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by the body's immune system mistakenly attacking healthy joint tissue causing inflammation, joint damage, disability, and a reduced life expectancy. The main objective of this study is to characterize attainment of minimal disease activity (MDA) at week 24 under continuous treatment with upadacitinib in participants with oligo- or polyarticular PsA as part of real-world practice. Upadacitinib is a drug approved for the treatment of Psoriatic arthritis (PsA) in Germany and Canada. Approximately 380 adult participants with PsA at multiple sites in Germany and Canada. Participants will receive oral Upadacitinib tablets per current local label, according to local standard of care and international guidelines. There may be a higher burden for participants in this study compared to standard of care. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and by questionnaire.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Diagnosis of active Psoriatic Arthritis (PsA) upon judgment of the treating physician.
  • - Swollen joint count (SJC) >= 1 out of 66 joints.
  • - Decision on the treatment with Upadacitinib was made prior to any decision to approach the participant to participate in this study.

Exclusion Criteria:

  • - Cannot be treated with Upadacitinib according to the local Upadacitinib Summary of Product Characteristics (SmPC).
  • - Prior treatment with Upadacitinib.
  • - Currently participating in interventional research or within the last 30 days.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04758117
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

ABBVIE INC.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Canada, Germany
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Psoriatic Arthritis
Study Website: View Trial Website
Arms & Interventions

Arms

: Participants Receiving Upadacitinib

Participants receiving Upadacitinib for psoriatic arthritis (PsA).

Interventions

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Manitoba Clinic /ID# 234148, Winnipeg, Manitoba, Canada

Status

Recruiting

Address

Manitoba Clinic /ID# 234148

Winnipeg, Manitoba, R3A 1M3

Nexus Clinical Research /ID# 239612, St. John's, Newfoundland and Labrador, Canada

Status

Recruiting

Address

Nexus Clinical Research /ID# 239612

St. John's, Newfoundland and Labrador, A1B 5E8

The Waterside Clinic /ID# 234146, Barrie, Ontario, Canada

Status

Recruiting

Address

The Waterside Clinic /ID# 234146

Barrie, Ontario, L4M 6L2

Etobicoke, Ontario, Canada

Status

Recruiting

Address

Arthur Karasik Medicine Professional Corporation /ID# 234147

Etobicoke, Ontario, M9C 5N2

Credit Valley Rheumatology /ID# 234144, Mississauga, Ontario, Canada

Status

Recruiting

Address

Credit Valley Rheumatology /ID# 234144

Mississauga, Ontario, L5M 2V8

Oshawa, Ontario, Canada

Status

Recruiting

Address

Dr. L. Lisnevskaia Medicine Professional Corporation /ID# 239611

Oshawa, Ontario, L1H 1B9

Ottawa, Ontario, Canada

Status

Recruiting

Address

Angela Montgomery Medicine Professional Corporation /ID# 239608

Ottawa, Ontario, K1H 7X3

Toronto Western Hospital /ID# 239610, Toronto, Ontario, Canada

Status

Recruiting

Address

Toronto Western Hospital /ID# 239610

Toronto, Ontario, M5T 2S8

Montreal, Quebec, Canada

Status

Recruiting

Address

Clinique de Rhumatologie de Montreal /ID# 239613

Montreal, Quebec, H4N 1C6

Centre de Recherche St-Louis /ID# 234150, Quebec City, Quebec, Canada

Status

Recruiting

Address

Centre de Recherche St-Louis /ID# 234150

Quebec City, Quebec, G1W 4R4

Sainte-foy, Quebec, Canada

Status

Recruiting

Address

Groupe de Recherche en Maladies Osseuses Inc /ID# 234145

Sainte-foy, Quebec, G1V 3M7

Trois-rivières, Quebec, Canada

Status

Recruiting

Address

Centre de Recherche Musculo-Squelettique /ID# 234151

Trois-rivières, Quebec, G8Z 1Y2

Dr. Latha Naik /ID# 234149, Saskatoon, Saskatchewan, Canada

Status

Recruiting

Address

Dr. Latha Naik /ID# 234149

Saskatoon, Saskatchewan, S7K 3H3

Praxis Dr. Rinaldi /ID# 228639, Ulm, Baden-Wuerttemberg, Germany

Status

Recruiting

Address

Praxis Dr. Rinaldi /ID# 228639

Ulm, Baden-Wuerttemberg, 89073

Munich, Bayern, Germany

Status

Recruiting

Address

Praxis Dres. Kellerer/Kellerer/Krüger /ID# 227414

Munich, Bayern, 81541

Potsdam, Brandenburg, Germany

Status

Recruiting

Address

Rheumahaus Studien GbR, Potsdam, DE /ID# 230771

Potsdam, Brandenburg, 14467

Gießen, Hessen, Germany

Status

Recruiting

Address

Internistisches Praxiszentrum /ID# 228262

Gießen, Hessen, 35392

Bruchhausen-Vilsen, Niedersachsen, Germany

Status

Recruiting

Address

Fachpraxis fuer Rheumatologie und Osteologie /ID# 227391

Bruchhausen-Vilsen, Niedersachsen, 27305

Kupka & Kupka, Altenburg, DE /ID# 228243, Altenburg, Germany

Status

Recruiting

Address

Kupka & Kupka, Altenburg, DE /ID# 228243

Altenburg, , 04600

Marycz, Amberg, DE /ID# 227413, Amberg, Germany

Status

Recruiting

Address

Marycz, Amberg, DE /ID# 227413

Amberg, , 92224

Rheumapraxis am Webereck /ID# 229274, Augsburg, Germany

Status

Recruiting

Address

Rheumapraxis am Webereck /ID# 229274

Augsburg, , 86157

MVZ Weserbergland /ID# 228806, Bad Pyrmont, Germany

Status

Recruiting

Address

MVZ Weserbergland /ID# 228806

Bad Pyrmont, , 31812

Baden-baden, Germany

Status

Recruiting

Address

ACURA Rheumazentrum Baden-Bade /ID# 239202

Baden-baden, , 76530

Bamberg, Germany

Status

Recruiting

Address

Rheumapraxis Prof Dr Karin Manger /ID# 229120

Bamberg, , 96047

Sozialstiftung Bamberg /ID# 228549, Bamberg, Germany

Status

Recruiting

Address

Sozialstiftung Bamberg /ID# 228549

Bamberg, , 96049

Bayreuth, Germany

Status

Recruiting

Address

Internistische-rheumatologische Praxisgemeinschaft /ID# 228240

Bayreuth, , 95444

Berlin, Germany

Status

Recruiting

Address

Praxis Dr. med. Angela Seifert /ID# 233772

Berlin, , 12555

Praxis Dr. Silke Zinke /ID# 229127, Berlin, Germany

Status

Recruiting

Address

Praxis Dr. Silke Zinke /ID# 229127

Berlin, , 13055

Berlin, Germany

Status

Recruiting

Address

Rheumapraxis am Schlachtensee /ID# 228800

Berlin, , 14129

Eisterhues, Braunschweig, DE /ID# 227390, Braunschweig, Germany

Status

Recruiting

Address

Eisterhues, Braunschweig, DE /ID# 227390

Braunschweig, , 38100

Dres. Schuh /ID# 227411, Coburg, Germany

Status

Recruiting

Address

Dres. Schuh /ID# 227411

Coburg, , 96450

Rheumatologie in Veedel /ID# 228469, Cologne, Germany

Status

Recruiting

Address

Rheumatologie in Veedel /ID# 228469

Cologne, , 50825

Krankenhaus Porz am Rhein /ID# 228358, Cologne, Germany

Status

Recruiting

Address

Krankenhaus Porz am Rhein /ID# 228358

Cologne, , 51149

Praxis Dr. Kirrstetter /ID# 229609, Deggendorf, Germany

Status

Recruiting

Address

Praxis Dr. Kirrstetter /ID# 229609

Deggendorf, , 94469

Kreiskrankenhaus Demmin /ID# 228253, Demmin, Germany

Status

Recruiting

Address

Kreiskrankenhaus Demmin /ID# 228253

Demmin, , 17109

Dresden, Germany

Status

Recruiting

Address

Rheumatologisches MVZ Dresden /ID# 230787

Dresden, , 01109

Praxis Dilltal /ID# 228640, Ehringshausen, Germany

Status

Recruiting

Address

Praxis Dilltal /ID# 228640

Ehringshausen, , 35630

Dres. Waehrisch/Flaxenberg /ID# 228263, Essen, Germany

Status

Recruiting

Address

Dres. Waehrisch/Flaxenberg /ID# 228263

Essen, , 45326

Freiberg, Germany

Status

Recruiting

Address

Michael Mueller, Freiberg, DE /ID# 228468

Freiberg, , 09599

Praxis Dr. Behringer /ID# 229275, Fulda, Germany

Status

Recruiting

Address

Praxis Dr. Behringer /ID# 229275

Fulda, , 36039

Rockwitz, Goslar, DE /ID# 227856, Goslar, Germany

Status

Recruiting

Address

Rockwitz, Goslar, DE /ID# 227856

Goslar, , 38642

Praxis Dr. Kuehne /ID# 229119, Haldensleben, Germany

Status

Recruiting

Address

Praxis Dr. Kuehne /ID# 229119

Haldensleben, , 39340

Praxis Dr. Liebhaber /ID# 228636, Halle, Germany

Status

Recruiting

Address

Praxis Dr. Liebhaber /ID# 228636

Halle, , 06128

Stille, Hanover, DE /ID# 229604, Hannover, Germany

Status

Recruiting

Address

Stille, Hanover, DE /ID# 229604

Hannover, , 30161

Heilig, Heidelberg, DE /ID# 228356, Heidelberg, Germany

Status

Recruiting

Address

Heilig, Heidelberg, DE /ID# 228356

Heidelberg, , 69120

Herne, Germany

Status

Recruiting

Address

St. Elisabeth Gruppe GmbH -Katholische Kliniken /ID# 228797

Herne, , 44649

Praxis Bernd Mueller /ID# 230776, Homburg, Germany

Status

Recruiting

Address

Praxis Bernd Mueller /ID# 230776

Homburg, , 66424

Praxis K. Pagel /ID# 228247, Hoppegarten, Germany

Status

Recruiting

Address

Praxis K. Pagel /ID# 228247

Hoppegarten, , 15366

Rheumapraxis Kaufering /ID# 231391, Kaufering, Germany

Status

Recruiting

Address

Rheumapraxis Kaufering /ID# 231391

Kaufering, , 86916

Alb-Donau Klinikum, Langenau /ID# 233770, Langenau, Germany

Status

Recruiting

Address

Alb-Donau Klinikum, Langenau /ID# 233770

Langenau, , 89129

Leipzig, Germany

Status

Recruiting

Address

Hamann & Teich & Boche,Leipzig /ID# 228355

Leipzig, , 04109

Leipzig, Germany

Status

Recruiting

Address

Praxis internistische Rheumatologie /ID# 227857

Leipzig, , 04129

Dres. Teipel/Toussaint/Saech /ID# 228465, Leverkusen, Germany

Status

Recruiting

Address

Dres. Teipel/Toussaint/Saech /ID# 228465

Leverkusen, , 51373

Dr. Bolze, Ludwigshafen, DE /ID# 230773, Ludwigshafen, Germany

Status

Recruiting

Address

Dr. Bolze, Ludwigshafen, DE /ID# 230773

Ludwigshafen, , 67069

Aurich & Sieburg, Magdeburg /ID# 229605, Magdeburg, Germany

Status

Recruiting

Address

Aurich & Sieburg, Magdeburg /ID# 229605

Magdeburg, , 39104

Mansfeld / Großörner, Germany

Status

Recruiting

Address

Praxis Dr. Annekatrin Rossbach /ID# 230783

Mansfeld / Großörner, , 06343

Harmuth, Marktredwitz, DE /ID# 227709, Marktredwitz, Germany

Status

Recruiting

Address

Harmuth, Marktredwitz, DE /ID# 227709

Marktredwitz, , 95615

RHIO Forschungsinstitut /ID# 227736, Meerbusch, Germany

Status

Recruiting

Address

RHIO Forschungsinstitut /ID# 227736

Meerbusch, , 40668

Prof-med-stud.de /ID# 228637, Munich, Germany

Status

Recruiting

Address

Prof-med-stud.de /ID# 228637

Munich, , 80935

Naumburg (Saale), Germany

Status

Recruiting

Address

Rheumatologische Facharztpraxis /ID# 228808

Naumburg (Saale), , 06618

Berger, Naunhof, DE /ID# 229612, Naunhof, Germany

Status

Recruiting

Address

Berger, Naunhof, DE /ID# 229612

Naunhof, , 04683

Praxis Dr. med Thilo Klopsch /ID# 229123, Neubrandenburg, Germany

Status

Recruiting

Address

Praxis Dr. med Thilo Klopsch /ID# 229123

Neubrandenburg, , 17033

Neunkirchen, Germany

Status

Recruiting

Address

Erbsloeh-Moeller, Neunkirchen /ID# 230778

Neunkirchen, , 66538

Pfarrkirchen, Germany

Status

Recruiting

Address

Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 230774

Pfarrkirchen, , 84347

Planegg, Germany

Status

Recruiting

Address

MVZ für Rheumatologie Dr. M. Welcker GmbH /ID# 227858

Planegg, , 82152

Baumann & Lang, Plauen, DE /ID# 229128, Plauen, Germany

Status

Recruiting

Address

Baumann & Lang, Plauen, DE /ID# 229128

Plauen, , 08523

Rheumazentrum Ratingen /ID# 228261, Ratingen, Germany

Status

Recruiting

Address

Rheumazentrum Ratingen /ID# 228261

Ratingen, , 40882

Rendsburg, Germany

Status

Recruiting

Address

Rheumatologische Praxis Dr. Jochen Walter /ID# 229607

Rendsburg, , 24768

Schwerin, Germany

Status

Recruiting

Address

Rheumatologische Gemeinschaftspraxis Schwerin /ID# 228260

Schwerin, , 19053

Melzer, Seesen, DE /ID# 227386, Seesen, Germany

Status

Recruiting

Address

Melzer, Seesen, DE /ID# 227386

Seesen, , 38723

Straubing, Germany

Status

Recruiting

Address

Barmherzige Bruder MVZ Klinikum Straubing GmbH /ID# 228805

Straubing, , 94315

Bruederkrankenhaus Trier /ID# 229603, Trier, Germany

Status

Recruiting

Address

Bruederkrankenhaus Trier /ID# 229603

Trier, , 54292

Praxis Dr. Haas /ID# 228813, Tuebingen, Germany

Status

Recruiting

Address

Praxis Dr. Haas /ID# 228813

Tuebingen, , 72072

Rheumathologie Ulm /ID# 238801, Ulm, Germany

Status

Recruiting

Address

Rheumathologie Ulm /ID# 238801

Ulm, , 89073

MVZ Lahn-Dill-Kliniken GmbH /ID# 231390, Wetzlar, Germany

Status

Recruiting

Address

MVZ Lahn-Dill-Kliniken GmbH /ID# 231390

Wetzlar, , 35578

Krankenhaus St. Josef /ID# 229611, Wuppertal, Germany

Status

Recruiting

Address

Krankenhaus St. Josef /ID# 229611

Wuppertal, , 42105

Praxis Barmen /ID# 227392, Wuppertal, Germany

Status

Recruiting

Address

Praxis Barmen /ID# 227392

Wuppertal, , 42285

Sprekeler, Zeven, DE /ID# 233773, Zeven, Germany

Status

Recruiting

Address

Sprekeler, Zeven, DE /ID# 233773

Zeven, , 27404

Fricke-Wagner, Zwickau, DE /ID# 230775, Zwickau, Germany

Status

Recruiting

Address

Fricke-Wagner, Zwickau, DE /ID# 230775

Zwickau, , 08060

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