A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease

Study Purpose

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Have a diagnosis of psoriatic arthritis (PsA) for at least 6 months prior to the first administration of study intervention and meet classification criteria for psoriatic arthritis (CASPAR) criteria at screening.
  • - Have active PsA as defined by: a) at least 3 swollen joints and at least 3 tender joints at screening and at baseline and b) C-reactive protein (CRP) greater than or equal to (>=) 0.3 milligram/deciliter (mg/dL) at screening from the central laboratory, and despite previous non-biologic disease modifying antirheumatic drug (DMARD), apremilast, and/or nonsteroidal anti-inflammatory drug (NSAID) therapy.
  • - Have magnetic resonance imaging (MRI)-confirmed PsA axial disease (positive MRI spine and/or sacroiliac [SI] joints, shown by a Spondyloarthritis Research Consortium of Canada [SPARCC] score of >= 3 in either the spine or the sacroiliac joints) - Have a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of at least 4, and have a spinal pain score (on a visual analog scale [VAS]) of at least 4.
  • - Have active plaque psoriasis, with at least 1 psoriatic plaque of >= 2 centimeter (cm) diameter and/or nail changes consistent with psoriasis, or documented history of plaque psoriasis.

Exclusion Criteria:

  • - Has known allergies, hypersensitivity, or intolerance to guselkumab or its excipients.
  • - Has other inflammatory diseases that might confound the evaluations of benefit of guselkumab therapy, including but not limited to rheumatoid arthritis (RA), ankylosing spondylitis (AS)/non-radiographic-axial spondyloarthritis (this does not include a primary diagnosis of PsA with spondylitis), systemic lupus erythematosus, or Lyme disease.
  • - Has previously received any biologic treatment.
  • - Has ever received a Janus kinase (JAK) inhibitor including but not limited to tofacitinib, baricitinib, filgotinib, peficitinib, decernotinib, upadacitinib or any other investigational JAK inhibitor.
- Has received any systemic immunosuppressants (example, azathioprine, cyclosporine, 6 thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, tacrolimus) within 4 weeks of the first administration of study intervention

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT04929210
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 4
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Janssen Research & Development, LLC
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Janssen Research & Development, LLC Clinical Trial
Principal Investigator Affiliation Janssen Research & Development, LLC
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries Argentina, Australia, Bulgaria, Canada, Czechia, Germany, Hong Kong, Hungary, Israel, Malaysia, Poland, Portugal, Russian Federation, Spain, Taiwan, Turkey, Ukraine, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Arthritis, Psoriatic
Study Website: View Trial Website
Additional Details

PsA is a chronic inflammatory musculoskeletal disease that has 6 disease domains, and axial disease represents one of the domains. Guselkumab is a fully human immunoglobulin (Ig) G1 lambda monoclonal antibody (mAb) that by binding to the p19 protein subunit of interleukin (IL)-23, blocks the binding of extracellular IL-23 to the cell surface IL-23 receptor, inhibiting IL-23-mediated intracellular signaling, activation, and cytokine production. This study will consist of a screening phase (up to 6 weeks), a treatment phase (up to 48 weeks, including a placebo-controlled period from Week 0 to Week 24 and an active-controlled treatment phase from Week 24 to Week 48), and a safety follow-up phase (up to Week 60). The efficacy assessments will include assessment such as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score and the safety assessments will include evaluations of physical examinations, vital signs, electrocardiograms, clinical laboratory tests, and adverse events. The overall duration of the study will be up to 14 months.

Arms & Interventions

Arms

Experimental: Group 1: Guselkumab and Placebo

Participants will receive guselkumab and matching placebo subcutaneously (SC) to maintain the blind.

Experimental: Group 2: Guselkumab

Participants will receive guselkumab SC.

Experimental: Group 3: Placebo followed by Guselkumab

Participants will receive matching placebo and will cross over to receive guselkumab SC.

Interventions

Drug: - Guselkumab

Guselkumab will be administered as subcutaneous injection.

Drug: - Placebo

Matching placebo will be administered as subcutaneous injection.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Mesa, Arizona

Status

Not yet recruiting

Address

Arizona Arthritis and Rheumatology Research, PLLC

Mesa, Arizona, 85210

Arizona Arthritis Research, PLC., Phoenix, Arizona

Status

Not yet recruiting

Address

Arizona Arthritis Research, PLC.

Phoenix, Arizona, 85032

Phoenix, Arizona

Status

Not yet recruiting

Address

Arizona Arthritis and Rheumatology Research, PLLC

Phoenix, Arizona, 85037

Sun City, Arizona

Status

Not yet recruiting

Address

Arizona Arthritis & Rheumatology Associates

Sun City, Arizona, 85351

Southern Arizona VA Healthcare System, Tucson, Arizona

Status

Not yet recruiting

Address

Southern Arizona VA Healthcare System

Tucson, Arizona, 85723

Medvin Clinical Research, Covina, California

Status

Not yet recruiting

Address

Medvin Clinical Research

Covina, California, 91722

Care Access Research - Huntington Beach, Huntington Beach, California

Status

Recruiting

Address

Care Access Research - Huntington Beach

Huntington Beach, California, 92648

Clinical Research Center of Connecticut, Danbury, Connecticut

Status

Not yet recruiting

Address

Clinical Research Center of Connecticut

Danbury, Connecticut, 06810

Bay Pines VA Healthcare System, Bay Pines, Florida

Status

Not yet recruiting

Address

Bay Pines VA Healthcare System

Bay Pines, Florida, 33744

Miami, Florida

Status

Not yet recruiting

Address

Baptist Health Medical Group General Surgery

Miami, Florida, 33173

Plantation, Florida

Status

Not yet recruiting

Address

Integral Rheumatology & Immunology Specialists

Plantation, Florida, 33324

Florida Medical Clinic, P.A., Zephyrhills, Florida

Status

Not yet recruiting

Address

Florida Medical Clinic, P.A.

Zephyrhills, Florida, 33542

Great Lakes Clinical Trials, Chicago, Illinois

Status

Recruiting

Address

Great Lakes Clinical Trials

Chicago, Illinois, 60640

Johns Hopkins Bayview Medical, Baltimore, Maryland

Status

Not yet recruiting

Address

Johns Hopkins Bayview Medical

Baltimore, Maryland, 21224

Klein & Associates, M.D., P.A., Hagerstown, Maryland

Status

Not yet recruiting

Address

Klein & Associates, M.D., P.A.

Hagerstown, Maryland, 21740

University of Michigan, Ann Arbor, Michigan

Status

Not yet recruiting

Address

University of Michigan

Ann Arbor, Michigan, 48109

Shores Rheumatology P.C., Saint Clair Shores, Michigan

Status

Not yet recruiting

Address

Shores Rheumatology P.C.

Saint Clair Shores, Michigan, 48081

St. Paul Rhuematology, P.A., Eagan, Minnesota

Status

Not yet recruiting

Address

St. Paul Rhuematology, P.A.

Eagan, Minnesota, 55121

STAT Research, Inc., Vandalia, Ohio

Status

Not yet recruiting

Address

STAT Research, Inc.

Vandalia, Ohio, 45377

Dr. Ramesh Gupta, Memphis, Tennessee

Status

Not yet recruiting

Address

Dr. Ramesh Gupta

Memphis, Tennessee, 38119

Austin Regional Clinic, Austin, Texas

Status

Recruiting

Address

Austin Regional Clinic

Austin, Texas, 78731

Colleyville, Texas

Status

Recruiting

Address

Precision Comprehensive Clinical Research Solutions

Colleyville, Texas, 76034

Adriana Pop Moody MD Clinic PA, Corpus Christi, Texas

Status

Not yet recruiting

Address

Adriana Pop Moody MD Clinic PA

Corpus Christi, Texas, 78404

Metroplex Clinical Research Center, Dallas, Texas

Status

Withdrawn

Address

Metroplex Clinical Research Center

Dallas, Texas, 75231

Fort Worth, Texas

Status

Not yet recruiting

Address

Precision Comprehensive Clinical Research Solutions

Fort Worth, Texas, 76107

Southwest Rheumatology Research LLC, Mesquite, Texas

Status

Not yet recruiting

Address

Southwest Rheumatology Research LLC

Mesquite, Texas, 75150

DM Clinical Research, Tomball, Texas

Status

Not yet recruiting

Address

DM Clinical Research

Tomball, Texas, 77375

International Sites

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Status

Not yet recruiting

Address

Hospital Italiano de Buenos Aires

Buenos Aires, , C1199ABB

Emeritus Research, Camberwell, Australia

Status

Not yet recruiting

Address

Emeritus Research

Camberwell, , 3124

Royal Prince Alfred Hospital, Camperdown, Australia

Status

Withdrawn

Address

Royal Prince Alfred Hospital

Camperdown, , 2050

Repatriation General Hospital, Daw Park, Australia

Status

Withdrawn

Address

Repatriation General Hospital

Daw Park, , 5041

St Vincent's hospital, Fitzroy, Australia

Status

Withdrawn

Address

St Vincent's hospital

Fitzroy, , 3065

Footscray, Australia

Status

Withdrawn

Address

Rheumatology Dept, University of Melbourne Clinical School, Western Hospital

Footscray, , 3011

Southern Clinical Research, Hobart, Australia

Status

Not yet recruiting

Address

Southern Clinical Research

Hobart, , 7000

Optimus Research, Kogarah, Australia

Status

Withdrawn

Address

Optimus Research

Kogarah, , 2217

Liverpool Hospital, Liverpool, Australia

Status

Not yet recruiting

Address

Liverpool Hospital

Liverpool, , NSW 1871

Skin Health Institute Inc., Melbourne, Australia

Status

Not yet recruiting

Address

Skin Health Institute Inc.

Melbourne, , 3053

Eastern Health - Box Hill Hospital, Melbourne, Australia

Status

Not yet recruiting

Address

Eastern Health - Box Hill Hospital

Melbourne, , 3128

John Hunter Hospital, New Lambton Heights, Australia

Status

Withdrawn

Address

John Hunter Hospital

New Lambton Heights, , 2305

Coast Joint Care, Maroochydore, Queensland, Australia

Status

Withdrawn

Address

Coast Joint Care, Maroochydore

Queensland, , 4558

RK Will Pty Ltd, Victoria Park, Australia

Status

Withdrawn

Address

RK Will Pty Ltd

Victoria Park, , 6100

Queen Elizabeth Hospital, Woodville South, Australia

Status

Withdrawn

Address

Queen Elizabeth Hospital

Woodville South, , 5011

Medical Center Unimed Plovdiv, Plovdiv, Bulgaria

Status

Not yet recruiting

Address

Medical Center Unimed Plovdiv

Plovdiv, , 4001

UMHAT 'St. Ivan Rilski', Sfia, Bulgaria

Status

Not yet recruiting

Address

UMHAT 'St. Ivan Rilski'

Sfia, , 1612

Military Medical Academy, Sofia, Bulgaria

Status

Not yet recruiting

Address

Military Medical Academy

Sofia, , 1606

Sofia, Bulgaria

Status

Not yet recruiting

Address

ASIMP Rheumatology Centre "St Irina" EOOD

Sofia, , 1750

Sofia, Bulgaria

Status

Not yet recruiting

Address

University Multiprofile Hospital Sofiamed Sofia

Sofia, , 1770

Medical Centre Synexus, Sofia, Bulgaria

Status

Not yet recruiting

Address

Medical Centre Synexus

Sofia, , 1794

DDC Sv. Ivan Rilski OOD, Targovishte, Bulgaria

Status

Not yet recruiting

Address

DDC Sv. Ivan Rilski OOD

Targovishte, , 7700

Skin Care Centre, Vancouver, British Columbia, Canada

Status

Not yet recruiting

Address

Skin Care Centre

Vancouver, British Columbia, V5Z 4E8

St. John's, Newfoundland and Labrador, Canada

Status

Not yet recruiting

Address

Eastern Regional Health Authority, St. Clare's Mercy Hospital

St. John's, Newfoundland and Labrador, A1C 5B8

Toronto Western Hospital, Toronto, Ontario, Canada

Status

Not yet recruiting

Address

Toronto Western Hospital

Toronto, Ontario, M5T 2S8

Quebec, Canada

Status

Not yet recruiting

Address

G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.

Quebec, , G1V 3M7

Revmacentrum MUDr. Mostera, s.r.o., Brno - Zidenice, Czechia

Status

Not yet recruiting

Address

Revmacentrum MUDr. Mostera, s.r.o.

Brno - Zidenice, , 615 00

Revmaclinic, Brno, Czechia

Status

Not yet recruiting

Address

Revmaclinic

Brno, , 61141

Revmatologie s.r.o., Brno, Czechia

Status

Not yet recruiting

Address

Revmatologie s.r.o.

Brno, , 63800

L.K.N Arthrocentrum, Hlucin, Czechia

Status

Recruiting

Address

L.K.N Arthrocentrum

Hlucin, , 748 01

MUDr. Rosypalova, s.r.o, Ostrava, Czechia

Status

Recruiting

Address

MUDr. Rosypalova, s.r.o

Ostrava, , 70800

Arthrohelp S.R.O., Pardubice, Czechia

Status

Withdrawn

Address

Arthrohelp S.R.O.

Pardubice, , 53002

Revmatologicky ustav, Praha, Czechia

Status

Recruiting

Address

Revmatologicky ustav

Praha, , 128 00

Medical Plus S.R.O., Uherske Hradiste, Czechia

Status

Recruiting

Address

Medical Plus S.R.O.

Uherske Hradiste, , 68601

Berlin, Germany

Status

Not yet recruiting

Address

ISA - Interdisciplinary Study Association GmbH

Berlin, , 10789

Katholisches Klinikum Bochum gGmbH, Bochum, Germany

Status

Withdrawn

Address

Katholisches Klinikum Bochum gGmbH

Bochum, , 44791

Universitatsklinikum Frankfurt, Frankfurt, Germany

Status

Not yet recruiting

Address

Universitatsklinikum Frankfurt

Frankfurt, , 60590

Hamburger Rheuma Forschungszentrum II, Hamburg, Germany

Status

Not yet recruiting

Address

Hamburger Rheuma Forschungszentrum II

Hamburg, , 20095

Hamburg, Germany

Status

Not yet recruiting

Address

Praxis fuer Rheumatologie Dr. med. Hauke E. Heintz

Hamburg, , 22391

Rheumazentrum Ruhrgebiet, Herne, Germany

Status

Not yet recruiting

Address

Rheumazentrum Ruhrgebiet

Herne, , 44649

Prince Of Wales Hospital, Hong Kong, Hong Kong

Status

Not yet recruiting

Address

Prince Of Wales Hospital

Hong Kong, ,

Budapest, Hungary

Status

Not yet recruiting

Address

Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz

Budapest, , 1023

Gyula, Hungary

Status

Not yet recruiting

Address

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz

Gyula, , 5700

Székesfehérvár, Hungary

Status

Not yet recruiting

Address

Fejer Megyei Szent Gyorgy Egyetemi Oktatokorhaz

Székesfehérvár, , 8000

Bnai Zion Medical Center, Haifa, Israel

Status

Not yet recruiting

Address

Bnai Zion Medical Center

Haifa, , 31048

Carmel Medical Center, Hifa, Israel

Status

Not yet recruiting

Address

Carmel Medical Center

Hifa, , 34362

Meir Medical Center, Kfar-Sava, Israel

Status

Not yet recruiting

Address

Meir Medical Center

Kfar-Sava, , 4428164

Sheba Medical Center, Ramat Gan, Israel

Status

Not yet recruiting

Address

Sheba Medical Center

Ramat Gan, , 5265601

Hospital Selayang, Batu Caves, Malaysia

Status

Not yet recruiting

Address

Hospital Selayang

Batu Caves, , 68100

Hospital Pulau Pinang, George Town, Malaysia

Status

Not yet recruiting

Address

Hospital Pulau Pinang

George Town, , 10990

University Malaya Medical Centre, Kuala Lumpur, Malaysia

Status

Recruiting

Address

University Malaya Medical Centre

Kuala Lumpur, , 59100

Hospital Tuanku Jaafar, Seremban, Malaysia

Status

Recruiting

Address

Hospital Tuanku Jaafar

Seremban, , 70300

ClinicMed Daniluk, Nowak Sp.J., Bialystok, Poland

Status

Recruiting

Address

ClinicMed Daniluk, Nowak Sp.J.

Bialystok, , 15-879

Szpital Uniwersytecki Nr 2 w Bydgoszczy, Bydgoszcz, Poland

Status

Not yet recruiting

Address

Szpital Uniwersytecki Nr 2 w Bydgoszczy

Bydgoszcz, , 85-168

Nzoz Bif-Med, Bytom, Poland

Status

Recruiting

Address

Nzoz Bif-Med

Bytom, , 41-902

Centrum Kliniczno Badawcze, Elblag, Poland

Status

Recruiting

Address

Centrum Kliniczno Badawcze

Elblag, , 82-300

Krakow, Poland

Status

Not yet recruiting

Address

Malopolskie Badania Kliniczne Sp. z o.o. Sp. k.

Krakow, , 30-002

Centrum Medyczne Promed, Krakow, Poland

Status

Not yet recruiting

Address

Centrum Medyczne Promed

Krakow, , 31-513

Lodz, Poland

Status

Not yet recruiting

Address

Centrum Terapii Wspolczesnej J. M. Jasnorzewska J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, , 90-242

Dermed Centrum Medyczne Sp. z o.o, Lodz, Poland

Status

Not yet recruiting

Address

Dermed Centrum Medyczne Sp. z o.o

Lodz, , 90-265

Centrum Medyczne AMED oddzial w Lodzi, Lodz, Poland

Status

Not yet recruiting

Address

Centrum Medyczne AMED oddzial w Lodzi

Lodz, , 91-363

ETG Lublin, Lublin, Poland

Status

Recruiting

Address

ETG Lublin

Lublin, , 20-412

NZOZ Lecznica MAK-MED. S.C., Nadarzyn, Poland

Status

Recruiting

Address

NZOZ Lecznica MAK-MED. S.C.

Nadarzyn, , 05-830

Centrum Badan Klinicznych, Poznan, Poland

Status

Not yet recruiting

Address

Centrum Badan Klinicznych

Poznan, , 60-446

Lubelskie Centrum Diagnostyczne, Swidnik, Poland

Status

Not yet recruiting

Address

Lubelskie Centrum Diagnostyczne

Swidnik, , 21-040

Nasz Lekarz Ośrodek Badań Klinicznych, Torun, Poland

Status

Not yet recruiting

Address

Nasz Lekarz Ośrodek Badań Klinicznych

Torun, , 87-100

Medycyna Kliniczna, Warsaw, Poland

Status

Recruiting

Address

Medycyna Kliniczna

Warsaw, , 00-874

Rheuma-Medicus, Zaklad Opieki Zdrowotnej, Warszawa, Poland

Status

Recruiting

Address

Rheuma-Medicus, Zaklad Opieki Zdrowotnej

Warszawa, , 02-118

Centrum Medyczne Reuma Park, Warszawa, Poland

Status

Recruiting

Address

Centrum Medyczne Reuma Park

Warszawa, , 02-691

ETG Warszawa, Warszawa, Poland

Status

Recruiting

Address

ETG Warszawa

Warszawa, , 02-793

Centrum Medyczne AMED Warszawa Targowek, Warszawa, Poland

Status

Not yet recruiting

Address

Centrum Medyczne AMED Warszawa Targowek

Warszawa, , 03-291

Wrocław, Poland

Status

Recruiting

Address

WroMedica I.Bielicka, A.Strzałkowska s.c.

Wrocław, , 51-685

Chlo - Hosp. Egas Moniz, Lisboa, Portugal

Status

Not yet recruiting

Address

Chlo - Hosp. Egas Moniz

Lisboa, , 1349-019

Hospital CUF Tejo, Lisboa, Portugal

Status

Not yet recruiting

Address

Hospital CUF Tejo

Lisboa, , 1350-352

Chln - Hosp. Santa Maria, Lisboa, Portugal

Status

Not yet recruiting

Address

Chln - Hosp. Santa Maria

Lisboa, , 1649-035

Ulsam - Hosp. Conde de Bertiandos, Ponte de Lima, Portugal

Status

Not yet recruiting

Address

Ulsam - Hosp. Conde de Bertiandos

Ponte de Lima, , 4990-041

Chsj - Hosp. Sao Joao, Porto, Portugal

Status

Not yet recruiting

Address

Chsj - Hosp. Sao Joao

Porto, , 4200-319

Altay Medical State University, Barnaul, Russian Federation

Status

Not yet recruiting

Address

Altay Medical State University

Barnaul, , 656038

Chelyabinck Regional Clinical Hospital, Chelyabinsk, Russian Federation

Status

Not yet recruiting

Address

Chelyabinck Regional Clinical Hospital

Chelyabinsk, , 454076

Chelyabinsk, Russian Federation

Status

Not yet recruiting

Address

Chelyabinsk Regional Clinical Dermatovenerological Dispensary

Chelyabinsk, , 454092

Ekaterinbourg, Russian Federation

Status

Not yet recruiting

Address

Sverdlovsk Regional Clinical Hospital N. 1

Ekaterinbourg, , 620102

Ekaterinburg, Russian Federation

Status

Not yet recruiting

Address

Research Institute of Dermatovenerology, Immunology

Ekaterinburg, , 620076

Izhevsk, Russian Federation

Status

Not yet recruiting

Address

Regional Clinical Diagnostic Center of Udmurtia Region

Izhevsk, , 426009

LLL Medical Center Revma-Med, Kemerovo, Russian Federation

Status

Not yet recruiting

Address

LLL Medical Center Revma-Med

Kemerovo, , 650070

LLC Family Outpatient Clinic # 4, Korolev, Russian Federation

Status

Recruiting

Address

LLC Family Outpatient Clinic # 4

Korolev, , 141060

Krasnoyarsk, Russian Federation

Status

Not yet recruiting

Address

Regional SBI of PH Krasnoyarsk Regional Clinical hospital #20 named after I.S. Berzon

Krasnoyarsk, , 660123

Lipetsk, Russian Federation

Status

Not yet recruiting

Address

Lipetsk Regional Dermatovenerological Dispensary

Lipetsk, , 398005

Moscow, Russian Federation

Status

Not yet recruiting

Address

Clinical-Diagnostic Center Euromedservice, JSC

Moscow, , 115419

Moscow, Russian Federation

Status

Not yet recruiting

Address

FGBU Research Institute of Rheumatology named V.A.Nasonova

Moscow, , 115522

Moscow, Russian Federation

Status

Not yet recruiting

Address

GBUZ of Moscow Region 'Moscow Region SRI n.a. Vladimirskyi'

Moscow, , 129110

Llc Ultramed, Omsk, Russian Federation

Status

Not yet recruiting

Address

Llc Ultramed

Omsk, , 644024

Orenburg, Russian Federation

Status

Not yet recruiting

Address

GBOU VPO Orenburg State Medical University

Orenburg, , 460000

GBUZ Perm Regional Clinical Hospital, Perm, Russian Federation

Status

Not yet recruiting

Address

GBUZ Perm Regional Clinical Hospital

Perm, , 614990

Republican Hospital n.a.V.A.Baranov, Petrozavodsk, Russian Federation

Status

Not yet recruiting

Address

Republican Hospital n.a.V.A.Baranov

Petrozavodsk, , 185019

Rostov, Russian Federation

Status

Not yet recruiting

Address

Rostov Regional Clinical Dermatovenerological Dispensary

Rostov, , 344007

St. Petersburg, Russian Federation

Status

Not yet recruiting

Address

St. Petersburg GBUZ Clinical Reumatological Hospital 25

St. Petersburg, , 190068

X7 Clinical Research Company Limited, St. Petersburg, Russian Federation

Status

Suspended

Address

X7 Clinical Research Company Limited

St. Petersburg, , 194156

Tolyatti, Russian Federation

Status

Not yet recruiting

Address

GBUZ of Samara Region 'Tolyatti City Clinical Hospital 5'

Tolyatti, , 445846

Ufa, Russian Federation

Status

Not yet recruiting

Address

Republican Clinical Hospital - G.G. Kuvatov

Ufa, , 450005

Yaroslavl, Russian Federation

Status

Not yet recruiting

Address

Clinical Emergency Hospital n.a. N.V. Solovyev

Yaroslavl, , 150003

Clinical Hospital #3, Yaroslavl, Russian Federation

Status

Not yet recruiting

Address

Clinical Hospital #3

Yaroslavl, , 150007

Hosp. Univ. A Coruña, A Coruña, Spain

Status

Not yet recruiting

Address

Hosp. Univ. A Coruña

A Coruña, , 15006

Hosp. Univ. de Cruces, Barakaldo, Spain

Status

Not yet recruiting

Address

Hosp. Univ. de Cruces

Barakaldo, , 48902

Hosp. Univ. de Basurto, Bilbao, Spain

Status

Not yet recruiting

Address

Hosp. Univ. de Basurto

Bilbao, , 48013

Hosp. Reina Sofia, Córdoba, Spain

Status

Recruiting

Address

Hosp. Reina Sofia

Córdoba, , 14004

Hosp. Clinico San Carlos, Madrid, Spain

Status

Recruiting

Address

Hosp. Clinico San Carlos

Madrid, , 28040

Hosp. Regional Univ. de Malaga, Málaga, Spain

Status

Recruiting

Address

Hosp. Regional Univ. de Malaga

Málaga, , 29009

Hosp. Univ. Marques de Valdecilla, Santander, Spain

Status

Withdrawn

Address

Hosp. Univ. Marques de Valdecilla

Santander, , 39008

Clinica Gaias, Santiago de Compostela, Spain

Status

Recruiting

Address

Clinica Gaias

Santiago de Compostela, , 15702

Hosp. Quiron Sagrado Corazon, Sevilla, Spain

Status

Not yet recruiting

Address

Hosp. Quiron Sagrado Corazon

Sevilla, , 41013

Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Status

Not yet recruiting

Address

Kaohsiung Veterans General Hospital

Kaohsiung, , 81362

Taichung Veterans General Hospital, Taichung, Taiwan

Status

Withdrawn

Address

Taichung Veterans General Hospital

Taichung, , 40705

National Cheng Kung University Hospital, Tainan, Taiwan

Status

Not yet recruiting

Address

National Cheng Kung University Hospital

Tainan, , 704

National Taiwan University Hospital, Taipei City, Taiwan

Status

Withdrawn

Address

National Taiwan University Hospital

Taipei City, , 10002

Gulhane Training and Research Hospital, Ankara, Turkey

Status

Not yet recruiting

Address

Gulhane Training and Research Hospital

Ankara, , 06010

Ankara Bilkent City Hospital, Ankara, Turkey

Status

Not yet recruiting

Address

Ankara Bilkent City Hospital

Ankara, , 06800

Hacettepe University Medical Faculty, Ankara, Turkey

Status

Not yet recruiting

Address

Hacettepe University Medical Faculty

Ankara, , 6100

Akdeniz University Medical Faculty, Antalya, Turkey

Status

Not yet recruiting

Address

Akdeniz University Medical Faculty

Antalya, , 7059

Uludag University Medical Faculty, Bursa, Turkey

Status

Not yet recruiting

Address

Uludag University Medical Faculty

Bursa, , 16059

Istanbul, Turkey

Status

Not yet recruiting

Address

Istanbul University Cerrahpasa Medical Faculty

Istanbul, , 34098

Marmara University Medical Faculty, Istanbul, Turkey

Status

Not yet recruiting

Address

Marmara University Medical Faculty

Istanbul, , 34899

Konya, Turkey

Status

Not yet recruiting

Address

Necmettin Erbakan University Meram Medical Faculty

Konya, , 42080

Cherkasy, Ukraine

Status

Not yet recruiting

Address

Communal Noncommercial Enterprise 'Cherkasy Regional Hospital of Cherkasy Regional Council'

Cherkasy, , 18009

Chernihiv, Ukraine

Status

Not yet recruiting

Address

Municipal health care institution Chernihiv Regional Hospital

Chernihiv, , 14029

Dnipro, Ukraine

Status

Not yet recruiting

Address

Ukrainian State Scientific And Research Institute Of Medical And Social Problems Of Disablement

Dnipro, , 49027

Kharkiv, Ukraine

Status

Not yet recruiting

Address

State Institution Institute of therapy named after L.T.Malaya AMS Ukraine

Kharkiv, , 61039

Kharkiv, Ukraine

Status

Not yet recruiting

Address

Municipal Institution Of Health Care Kharkiv City Policlinic # 24

Kharkiv, , 61064

Kharkiv, Ukraine

Status

Recruiting

Address

Municipal Institution Regional hospital-center of emergency care and disasters medicine

Kharkiv, , 61204

Kherson, Ukraine

Status

Not yet recruiting

Address

Mi 'Kherson City Clinical Hospital Of E.E. Karabelesh'

Kherson, , 73000

Khmelnitckiy regional hospital, Khmelnytsky, Ukraine

Status

Not yet recruiting

Address

Khmelnitckiy regional hospital

Khmelnytsky, , 29000

City Clinical Hospital No. 2, Kryvyi Rih, Ukraine

Status

Not yet recruiting

Address

City Clinical Hospital No. 2

Kryvyi Rih, , 50056

Kyiv, Ukraine

Status

Not yet recruiting

Address

Medical Center of 'Institute of Rheumatology', LLC

Kyiv, , 02081

Kyiv, Ukraine

Status

Not yet recruiting

Address

Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud

Kyiv, , 03037

Kyiv, Ukraine

Status

Not yet recruiting

Address

Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway'

Kyiv, , 03049

Kyiv, Ukraine

Status

Not yet recruiting

Address

SI 'National Scientific Center Institute of Cardiology of M.D. Strazhesko' of NAMS of Ukraine

Kyiv, , 03680

Kyiv, Ukraine

Status

Not yet recruiting

Address

Municipal Non-Profit Enterprise of Kyiv Regional Council 'Kyiv regional Clinical Hospital'

Kyiv, , 04107

Volyn Regional Clinical Hospital, Lutsk, Ukraine

Status

Not yet recruiting

Address

Volyn Regional Clinical Hospital

Lutsk, , 43005

Lviv, Ukraine

Status

Not yet recruiting

Address

Danylo Halytsky Lviv National Medical University

Lviv, , 79010

Odessa, Ukraine

Status

Not yet recruiting

Address

Municipal Non-profit Enterprise 'Odesa Regional Clinical Hospital' Odesa Regional Council

Odessa, , 65025

LLC Medical House, Odessa, Ukraine

Status

Not yet recruiting

Address

LLC Medical House

Odessa, , 65026

Poltava, Ukraine

Status

Not yet recruiting

Address

ME 'Poltava Regional Clinical Hospital named after M.V. Sklifosovsky of Poltava Regional Consuil'

Poltava, , 36011

Sumy, Ukraine

Status

Not yet recruiting

Address

Municipal Institution of Sumy Regional Council Sumy Regional Clinical Hospital

Sumy, , 40031

Ternopil, Ukraine

Status

Not yet recruiting

Address

Municipal institution of Tepnopil Regional Council 'Ternopil University Hospital'

Ternopil, , 46002

Uzhgorod, Ukraine

Status

Not yet recruiting

Address

MNCE Zakarpatska Regional Clinical Hospital named after A Novak of Zakarpatska Regional Council

Uzhgorod, , 88000

Health Clinic Limited Liability Company, Vinnytsia, Ukraine

Status

Not yet recruiting

Address

Health Clinic Limited Liability Company

Vinnytsia, , 21009

Vinnytsya, Ukraine

Status

Not yet recruiting

Address

Vinnitsia Regional Clinical Hospital n.a. M. I. Pyrogov

Vinnytsya, , 21018

Zaporizhzhya, Ukraine

Status

Not yet recruiting

Address

Communal Institution City Clinical Hospital #6 Of Zaporizhzhya City

Zaporizhzhya, , 69035

Medical Center LLC 'Modern Clinic', Zaporizhzhya, Ukraine

Status

Not yet recruiting

Address

Medical Center LLC 'Modern Clinic'

Zaporizhzhya, , 69600

Zhytomir, Ukraine

Status

Not yet recruiting

Address

Municipal institution Central Clinical Hospital #1 Zhytomir

Zhytomir, , 10002

Royal Free London NHS Foundation Trust, Barnet, United Kingdom

Status

Not yet recruiting

Address

Royal Free London NHS Foundation Trust

Barnet, , EN5 3DJ

Chapel Allerton Hospital, Leeds, United Kingdom

Status

Not yet recruiting

Address

Chapel Allerton Hospital

Leeds, , LS7 4SA

North Tyneside General Hospital, Newcastle, United Kingdom

Status

Not yet recruiting

Address

North Tyneside General Hospital

Newcastle, , NE29 8NH

Haywood Hospital, Stoke on Trent, United Kingdom

Status

Not yet recruiting

Address

Haywood Hospital

Stoke on Trent, , ST6 7AG

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