Clinical Trial Finder

Inclusion Criteria:

• - Subject has provided informed consent.

• - Diagnosis of chronic plaque psoriasis with or without psoriatic arthritis for at least 6 months prior to Screening.

• - Psoriasis Area and Severity Index(PASI)>=12 and body surface area(BSA) >=10% and static Physician's Global Assessment (sPGA) score 3 or greater on a 5-point scale.

• - Candidates for systemic psoriasis therapy and/or phototherapy and/or chemo phototherapy.

• - Women who are at childbearing age(not pregnant or breast-feeding), and subjects and their partners voluntarily use contraceptive methods deemed effective by the investigator during treatment and for at least 6 months after the last study medication.

Exclusion Criteria:

• - Forms of psoriasis other than chronic plaque psoriasis.

• - History or evidence of active tuberculosis, Patients with evidence of latent tuberculosis may enter the trial after sufficient treatment according to protocol.

• - Positive results of confirmatory serology test for hepatitis B, hepatitis C, HIV or syphilis at screening.

• - History of a serious or systemic infection within 4 weeks before screening.

• - History of malignancy of any organ system within the past 5 years.

• - Inadequate washout period for prior drug therapy.

• - Previous use of secukinumab, ixekizumab or any other drug that targets Interleukin 17( IL-17) or IL-17 receptor.

• - Any medical conditions, in the opinion of the Investigator or the Sponsor's medical monitor, would place the subject at risk, interfere with study participation or study results interpretation.

This is a randomized, double-blind, placebo-controlled, multi-center Phase 2 study to evaluate the efficacy and safety of HB0017 in subjects with moderate to severe plaque psoriasis. The study will consist of 3 periods: up to 5 weeks screening period, 28 weeks treatment period, 8 weeks Safety Follow-Up period.

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