An Observational Study to Assess Change in Disease Activity and Treatment Patterns of Upadacitinib When Given Alone or Co-Administered With Methotrexate in Adult Participants With Active Psoriatic Arthritis

Study Purpose

Psoriatic arthritis (PsA) is a chronic, immune-mediated, systemic disease affecting less than 1% of people with variations by parts of the world, and around 20%-30% of participants with psoriasis. Upadacitinib (RINVOQ) is approved drug for the treatment of adult participants with active PsA in Europe. Approximately 450 adult participants who are prescribed Upadacitinib by their physician in accordance with local label will be enrolled in 4 countries in Europe: France, Germany, Greece and Italy. Participants will receive upadacitinib as prescribed by their physician according to their routine clinical practice and local label. Participants will be followed for up to 24 months. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Observational
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Confirmed diagnosis of active psoriatic arthritis (PsA) whose peripheral involvement justifies the prescription of upadacitinib upon judgement of the treating physician.
  • - Physician decision on participant treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
  • - Upadacitinib prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies.
  • - Participants able to understand and communicate with the investigator and comply with the requirements of the study.

Exclusion Criteria:

  • - Participation in a clinical trial of an investigational drug, concurrently or within the last 30 days.
  • - Prior treatment with upadacitinib.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT05616871
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

AbbVie
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

ABBVIE INC.
Principal Investigator Affiliation AbbVie
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries France, Germany, Greece, Italy
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Psoriatic Arthritis
Study Website: View Trial Website
Arms & Interventions

Arms

: Upadacitinib Alone or In Combination with Methotrexate

Participants will receive upadacitinib alone or in combination with methotrexate as prescribed by their physician according to local label in real- world practice.

Interventions

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Troyes, Aube, France

Status

Recruiting

Address

CH Troyes - Hopital Simone Veil /ID# 252625

Troyes, Aube, 10000

CHU Limoges - Dupuytren 1 /ID# 252432, Limoges CEDEX 1, Franche-Comte, France

Status

Recruiting

Address

CHU Limoges - Dupuytren 1 /ID# 252432

Limoges CEDEX 1, Franche-Comte, 87042

Bordeaux, Gironde, France

Status

Recruiting

Address

CHU Bordeaux - Hopital Pellegrin /ID# 252532

Bordeaux, Gironde, 33076

TOULOUSE Cedex 9, Haute-Garonne, France

Status

Recruiting

Address

CHU Toulouse - Hopital Purpan /ID# 252077

TOULOUSE Cedex 9, Haute-Garonne, 31059

Montpellier Cedex 5, Herault, France

Status

Recruiting

Address

CHU Montpellier - Hopital Saint Eloi /ID# 252078

Montpellier Cedex 5, Herault, 34295

La Tronche, Isere, France

Status

Recruiting

Address

CHU Grenoble - Hopital Michallon /ID# 252601

La Tronche, Isere, 38700

Ch Beauvais /Id# 252464, Beauvais CEDEX, Oise, France

Status

Recruiting

Address

Ch Beauvais /Id# 252464

Beauvais CEDEX, Oise, 60021

CHU Nice -Hopital Pasteur /ID# 252536, Nice CEDEX 1, Provence-Alpes-Cote-d Azur, France

Status

Recruiting

Address

CHU Nice -Hopital Pasteur /ID# 252536

Nice CEDEX 1, Provence-Alpes-Cote-d Azur, 06002

Infirmerie Protestante /ID# 252075, Caluire Et Cuire, Rhone, France

Status

Recruiting

Address

Infirmerie Protestante /ID# 252075

Caluire Et Cuire, Rhone, 69300

CHU Amiens-Picardie Site Sud /ID# 252527, Amiens CEDEX 1, Somme, France

Status

Recruiting

Address

CHU Amiens-Picardie Site Sud /ID# 252527

Amiens CEDEX 1, Somme, 80054

Peronne, Somme, France

Status

Recruiting

Address

Cabinet libéral du Dr PAUPIERE /ID# 252604

Peronne, Somme, 80200

CH Henri Duffaut /ID# 252620, Avignon CEDEX 9, Vaucluse, France

Status

Recruiting

Address

CH Henri Duffaut /ID# 252620

Avignon CEDEX 9, Vaucluse, 84902

Aix Les Bains, France

Status

Recruiting

Address

CH AIX LES BAIN - Reine Hortense /ID# 252465

Aix Les Bains, , 73100

Antibes, France

Status

Recruiting

Address

Cabinet Médical Dr ALBERT-SABONNADIERE /ID# 252523

Antibes, , 06000

Centre Hospitalier d'Arras /ID# 252529, Arras, France

Status

Recruiting

Address

Centre Hospitalier d'Arras /ID# 252529

Arras, , 62022

Boulogne sur Mer, France

Status

Recruiting

Address

Centre Hospitalier de Boulogne Sur Mer /ID# 252467

Boulogne sur Mer, , 62200

CH de Cannes - Simone Veil /ID# 252600, Cannes, France

Status

Recruiting

Address

CH de Cannes - Simone Veil /ID# 252600

Cannes, , 06400

Chambray Les Tours, France

Status

Recruiting

Address

CHRU Tours - Hopital Trousseau /ID# 252528

Chambray Les Tours, , 37170

C. H. Sud Francilien /ID# 254945, Corbeil Essonnes, France

Status

Recruiting

Address

C. H. Sud Francilien /ID# 254945

Corbeil Essonnes, , 91106

La Rochelle, France

Status

Recruiting

Address

CH La Rochelle - Hopital Saint Louis /ID# 252534

La Rochelle, , 17019

Montauban, France

Status

Recruiting

Address

ELSAN - Clinique du Pont de Chaume /ID# 252602

Montauban, , 82000

CH de Narbonne /ID# 252525, Narbonne, France

Status

Recruiting

Address

CH de Narbonne /ID# 252525

Narbonne, , 11100

Orléans, France

Status

Recruiting

Address

Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 252530

Orléans, , 45067

Paris, France

Status

Recruiting

Address

GH Diaconesses Croix Saint-Simon /ID# 252463

Paris, , 75020

CHU de Rennes - Hospital Sud /ID# 252478, Rennes CEDEX 2, France

Status

Recruiting

Address

CHU de Rennes - Hospital Sud /ID# 252478

Rennes CEDEX 2, , 35203

Hôpital Charles-Nicolle /ID# 252603, Rouen, France

Status

Recruiting

Address

Hôpital Charles-Nicolle /ID# 252603

Rouen, , 76000

St Pierre, France

Status

Recruiting

Address

Cabinet Du Dr Judith Payet Dubourg /Id# 252668

St Pierre, , 97410

Dr. Murawski /ID# 257911, Neunkirchen, Saarland, Germany

Status

Recruiting

Address

Dr. Murawski /ID# 257911

Neunkirchen, Saarland, 66538

Rheumapraxis Dr. Prothmann /ID# 254759, Püttlingen, Saarland, Germany

Status

Recruiting

Address

Rheumapraxis Dr. Prothmann /ID# 254759

Püttlingen, Saarland, 66346

Kupka & Kupka, Altenburg, DE /ID# 254758, Altenburg, Germany

Status

Recruiting

Address

Kupka & Kupka, Altenburg, DE /ID# 254758

Altenburg, , 04600

Berlin, Germany

Status

Recruiting

Address

Rheumatologische Schwerpunktpraxis Brandt-Juergens /ID# 258152

Berlin, , 12161

Praxis Dr. Silke Zinke /ID# 258037, Berlin, Germany

Status

Recruiting

Address

Praxis Dr. Silke Zinke /ID# 258037

Berlin, , 13055

Brunswick, Germany

Status

Recruiting

Address

MVZ Herzogin Elisabeth Hospital /ID# 266740

Brunswick, , 38114

Praxis Dilltal /ID# 254761, Ehringshausen, Germany

Status

Recruiting

Address

Praxis Dilltal /ID# 254761

Ehringshausen, , 35630

Erfurt, Germany

Status

Recruiting

Address

MVZ Ambulantes Rheumazentrum Erfurt /ID# 256115

Erfurt, , 99096

Greifswald, Germany

Status

Recruiting

Address

Universitaetsmedizin Greifswald /ID# 254756

Greifswald, , 17475

Dr. Heintz /ID# 254757, Hamburg, Germany

Status

Recruiting

Address

Dr. Heintz /ID# 254757

Hamburg, , 22391

Rheumazentrum Ruhrgebiet /ID# 252939, Herne, Germany

Status

Recruiting

Address

Rheumazentrum Ruhrgebiet /ID# 252939

Herne, , 44649

Beyer, Kaiserslautern, DE /ID# 254754, Kaiserslautern, Germany

Status

Recruiting

Address

Beyer, Kaiserslautern, DE /ID# 254754

Kaiserslautern, , 67659

Dr. Bolze, Ludwigshafen, DE /ID# 254134, Ludwigshafen, Germany

Status

Completed

Address

Dr. Bolze, Ludwigshafen, DE /ID# 254134

Ludwigshafen, , 67069

Aurich & Sieburg, Magdeburg /ID# 255504, Magdeburg, Germany

Status

Recruiting

Address

Aurich & Sieburg, Magdeburg /ID# 255504

Magdeburg, , 39104

RHIO Forschungsinstitut /ID# 254752, Meerbusch, Germany

Status

Recruiting

Address

RHIO Forschungsinstitut /ID# 254752

Meerbusch, , 40668

Prof-med-stud.de /ID# 265965, Munich, Germany

Status

Recruiting

Address

Prof-med-stud.de /ID# 265965

Munich, , 80935

Knappschaftsklinikum Saar /ID# 255505, Puettlingen, Germany

Status

Recruiting

Address

Knappschaftsklinikum Saar /ID# 255505

Puettlingen, , 66346

Trier, Germany

Status

Recruiting

Address

Krankenhaus der Barmherzigen Brüder Trier /ID# 254762

Trier, , 54292

Krankenhaus St. Josef /ID# 254755, Wuppertal, Germany

Status

Recruiting

Address

Krankenhaus St. Josef /ID# 254755

Wuppertal, , 42105

Olympion General Clinic /ID# 247644, Patras, Achaia, Greece

Status

Recruiting

Address

Olympion General Clinic /ID# 247644

Patras, Achaia, 25443

Athens, Attiki, Greece

Status

Recruiting

Address

251 Airforce General Hospital /ID# 248092

Athens, Attiki, 11525

Athens, Attiki, Greece

Status

Recruiting

Address

Henry Dunnant Hospital Center /ID# 247640

Athens, Attiki, 11526

Athens, Attiki, Greece

Status

Recruiting

Address

General Hospital of Athens Gennimatas /ID# 247635

Athens, Attiki, 11527

Athens, Attiki, Greece

Status

Recruiting

Address

General Hospital of Athens Ippokratio /ID# 247633

Athens, Attiki, 11527

Athens, Attiki, Greece

Status

Active, not recruiting

Address

General Hospital of Athens Laiko /ID# 247634

Athens, Attiki, 11527

Athens, Attiki, Greece

Status

Recruiting

Address

General Hospital of Athens Laiko /ID# 258030

Athens, Attiki, 11527

Athens, Attiki, Greece

Status

Recruiting

Address

University General Hospital Attikon /ID# 248093

Athens, Attiki, 12462

Heraklion, Kriti, Greece

Status

Recruiting

Address

University General Hospital of Heraklion PA.G.N.I /ID# 247632

Heraklion, Kriti, 71500

Naval Hospital of Athens /ID# 247631, Athens, Greece

Status

Recruiting

Address

Naval Hospital of Athens /ID# 247631

Athens, , 11521

KAT Atttica General Hospital /ID# 247641, Athens, Greece

Status

Recruiting

Address

KAT Atttica General Hospital /ID# 247641

Athens, , 14561

Ioannina, Greece

Status

Recruiting

Address

University General Hospital of Ioannina /ID# 251899

Ioannina, , 45500

Iaso Thessalias S.A. /Id# 255110, Larisa, Greece

Status

Recruiting

Address

Iaso Thessalias S.A. /Id# 255110

Larisa, , 41005

Reg Gen Univ Hosp Larissa /ID# 247642, Larisa, Greece

Status

Recruiting

Address

Reg Gen Univ Hosp Larissa /ID# 247642

Larisa, , 41110

Magoula (Attikis), Greece

Status

Completed

Address

General Hospital of Elefsina Thriassio /ID# 251900

Magoula (Attikis), , 19018

Iaso /ID# 247649, Maroussi, Greece

Status

Recruiting

Address

Iaso /ID# 247649

Maroussi, , 15123

Bioclinic Thessaloniki /ID# 247648, Thessaloniki, Greece

Status

Recruiting

Address

Bioclinic Thessaloniki /ID# 247648

Thessaloniki, , 54622

Thessaloniki, Greece

Status

Recruiting

Address

Euromedica Blue Cross Gen Clin /ID# 251898

Thessaloniki, , 54636

Thessaloniki, Greece

Status

Recruiting

Address

General Hospital of Thessaloniki Hippokrateio /ID# 247643

Thessaloniki, , 54642

Euromedica General Clinic /ID# 251897, Thessaloniki, Greece

Status

Recruiting

Address

Euromedica General Clinic /ID# 251897

Thessaloniki, , 54645

Torette, Ancona, Italy

Status

Active, not recruiting

Address

Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 250819

Torette, Ancona, 60020

Rome, Lazio, Italy

Status

Active, not recruiting

Address

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 250669

Rome, Lazio, 00168

Ospedale San Raffaele IRCCS /ID# 251562, Milan, Milano, Italy

Status

Active, not recruiting

Address

Ospedale San Raffaele IRCCS /ID# 251562

Milan, Milano, 20132

Istituto Clinico Humanitas /ID# 251275, Rozzano, Milano, Italy

Status

Active, not recruiting

Address

Istituto Clinico Humanitas /ID# 251275

Rozzano, Milano, 20089

Rome, Roma, Italy

Status

Active, not recruiting

Address

Fondazione PTV Policlinico Tor Vergata /ID# 250817

Rome, Roma, 00133

Bari, Italy

Status

Active, not recruiting

Address

Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 251508

Bari, , 70124

Campobasso, Italy

Status

Active, not recruiting

Address

Universita degli Studi del Molise /ID# 251176

Campobasso, , 86100

Napoli, Italy

Status

Active, not recruiting

Address

AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 251183

Napoli, , 80138

Palermo, Italy

Status

Active, not recruiting

Address

Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 250789

Palermo, , 90127

Fondazione IRCCS Policlinico /ID# 250747, Pavia, Italy

Status

Active, not recruiting

Address

Fondazione IRCCS Policlinico /ID# 250747

Pavia, , 27100

Siena, Italy

Status

Active, not recruiting

Address

Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 251146

Siena, , 53100

Udine, Italy

Status

Active, not recruiting

Address

Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 251544

Udine, , 33100

The content provided on clinical trials is for informational purposes only and is not a substitute for medical consultation with your healthcare provider. We do not recommend or endorse any specific study and you are advised to discuss the information shown with your healthcare provider. While we believe the information presented on this website to be accurate at the time of writing, we do not guarantee that its contents are correct, complete, or applicable to any particular individual situation. We strongly encourage individuals to seek out appropriate medical advice and treatment from their physicians. We cannot guarantee the availability of any clinical trial listed and will not be responsible if you are considered ineligible to participate in a given clinical trial. We are also not liable for any injury arising as a result of participation.