Clinical Trial Finder

Inclusion Criteria:

• - Female participants of non-childbearing potential and male participants.

• - Age 18 to 75 years (both inclusive) at the time of informed consent.

• - Diagnosis of chronic plaque psoriasis for at least 6 months prior to randomisation, as confirmed by their medical record or history.

• - Moderate to severe plaque psoriasis, as defined by: - Body surface area (BSA) ≥5% and <30% - Static Physician's Global Assessment (sPGA) ≥3.

• - Target lesions suitable for skin biopsy.

• - Body mass index (BMI) <35 kg/m2.

• - Male participants able to father a child must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly.

A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information.

• - Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial.

Exclusion Criteria:

• - Non-plaque forms of psoriasis, current drug-induced psoriasis, or active ongoing inflammatory diseases other than psoriasis that might confound trial evaluations.

• - Major surgery (major according to the investigator's assessment, e.g. hip replacement) performed within 16 weeks prior to randomisation or planned during the trial (i.e. until the End of Study Visit) - Women of childbearing potential (WOCBP), breastfeeding women, and men unwilling or unable to use highly effective methods of birth control.

• - Any documented active or suspected malignancy or history of malignancy within 5 years prior to screening.

• - Live or attenuated vaccination ≤6 weeks prior to randomisation, or any plan to receive a live vaccination during the conduct of this trial until the End of Treatment Visit.

• - Participants who must or wish to continue the intake of restricted medications or any drug considered likely to interfere with the safe conduct of the trial.

• - Hepatic/renal impairment: - Hepatic impairment defined as >3-fold Upper Limit of Normal (ULN) elevation in AST or ALT or alkaline phosphatase, or >2-fold ULN elevation in total bilirubin.

Trial participants with Gilbert´s syndrome can be included unless total bilirubin elevation was >5-fold ULN at screening visit and unless proportions of bilirubin fractions are inconsistent with diagnosis of Gilbert´s syndrome.

• - Renal impairment defined as estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2.

- Currently enrolled in an investigational drug or device study, or use of any investigational drug or device within 4 weeks prior to randomisation or 5 half-lives of the drug (whichever is longer) Further exclusion criteria apply

Arms

Experimental: BI 765250 very low dose group

Placebo Comparator: Placebo group

Experimental: BI 765250 low dose group

Experimental: BI 765250 medium dose group

Experimental: BI 765250 high dose group

Interventions

Drug: - BI 765250

BI 765250

Drug: - Placebo

placebo