A Study of JNJ-77242113 for the Treatment of Participants With Plaque Psoriasis Involving Special Areas (Scalp, Genital, and/or Palms of the Hands and the Soles of the Feet)

Study Purpose

The purpose of the study is to see how effective JNJ-77242113 is in participants with plaque psoriasis affecting special areas (scalp, genital, and/or palms of the hands and the soles of the feet).

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 12 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention.
  • - Candidate for phototherapy or systemic treatment for plaque psoriasis.
  • - Need to meet criteria: Total body surface area (BSA) greater than or equal to (>=)1 percent (%) at screening and baseline, and investigator global assessment (IGA) (overall) >=2 at screening and baseline and at least one of the following: scalp-specific investigator global assessment (ss-IGA) score >=3 at screening and baseline, and/or static physician's global assessment of genitalia (sPGA-G) >=3 at screening and baseline, and/or physician's global assessment of hands and feet (hf-PGA) score >=3 at screening and baseline.
  • - Failed to respond to at least 1 topical therapy (example, corticosteroids, calcineurin inhibitors, and/or vitamin D analogs) used for treatment of psoriasis.
  • - Confirmation of plaque psoriasis in a non-special area (example, areas excluding scalp, genital, palmoplantar) at screening and baseline.

Exclusion Criteria:

  • - Nonplaque form of psoriasis (example, erythrodermic, guttate, or pustular) - Dermatoses other than plaque psoriasis (such as contact dermatitis) or palmoplantar pustulosis of the palmoplantar area (if hf-PGA >=3 at baseline) - Current drug-induced psoriasis (example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) - A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances.
- Known allergies, hypersensitivity, or intolerance to JNJ-77242113 or its excipients

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT06095102
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Janssen Research & Development, LLC
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Janssen Research &Development, LLC Clinical trial
Principal Investigator Affiliation Janssen Research & Development, LLC
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Active, not recruiting
Countries Argentina, Canada, Germany, Hungary, Korea, Republic of, Poland, Spain, Taiwan, Turkey, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Plaque Psoriasis
Arms & Interventions

Arms

Experimental: JNJ-77242113

Participants will receive JNJ-77242113 from Week 0 through Week 156.

Placebo Comparator: Placebo

Participants will receive placebo from Week 0 through Week 16 and thereafter will receive JNJ-77242113 from Week 16 through Week 156.

Interventions

Drug: - JNJ-77242113

JNJ-77242113 will be administered orally.

Drug: - Placebo

Placebo will be administered orally.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Scottsdale, Arizona

Status

Address

Center for Dermatology and Plastic Surgery

Scottsdale, Arizona, 85260

Johnson Dermatology, Fort Smith, Arkansas

Status

Address

Johnson Dermatology

Fort Smith, Arkansas, 72916

Encinitas, California

Status

Address

California Dermatology & Clinical Research Institute

Encinitas, California, 92024

Forcare Clinical Research Inc, Tampa, Florida

Status

Address

Forcare Clinical Research Inc

Tampa, Florida, 33613

Hamilton Research, LLC., Alpharetta, Georgia

Status

Address

Hamilton Research, LLC.

Alpharetta, Georgia, 30022

Arlington Dermatology, Rolling Meadows, Illinois

Status

Address

Arlington Dermatology

Rolling Meadows, Illinois, 60008

Dundee Dermatology, West Dundee, Illinois

Status

Address

Dundee Dermatology

West Dundee, Illinois, 60118

Indianapolis, Indiana

Status

Address

Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250

Indiana Clinical Trial Center, Plainfield, Indiana

Status

Address

Indiana Clinical Trial Center

Plainfield, Indiana, 46168

Dermatology and Advanced Aesthetics, Lake Charles, Louisiana

Status

Address

Dermatology and Advanced Aesthetics

Lake Charles, Louisiana, 70605

Allcutis Research, Beverly, Massachusetts

Status

Address

Allcutis Research

Beverly, Massachusetts, 01915

Hamzavi Dermatology, Fort Gratiot, Michigan

Status

Address

Hamzavi Dermatology

Fort Gratiot, Michigan, 48059

Minnesota Clinical Study Center, New Brighton, Minnesota

Status

Address

Minnesota Clinical Study Center

New Brighton, Minnesota, 55112

MediSearch Clinical Trials, Saint Joseph, Missouri

Status

Address

MediSearch Clinical Trials

Saint Joseph, Missouri, 64506

Skin Specialists, Omaha, Nebraska

Status

Address

Skin Specialists

Omaha, Nebraska, 68144

Windsor Dermatology, East Windsor, New Jersey

Status

Address

Windsor Dermatology

East Windsor, New Jersey, 08520

Optima Research, Boardman, Ohio

Status

Address

Optima Research

Boardman, Ohio, 44512

Oregon Dermatology and Research Center, Portland, Oregon

Status

Address

Oregon Dermatology and Research Center

Portland, Oregon, 97210

Paddington Testing Co, Inc., Philadelphia, Pennsylvania

Status

Address

Paddington Testing Co, Inc.

Philadelphia, Pennsylvania, 19103

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Status

Address

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213

Arlington Research Center, Inc., Arlington, Texas

Status

Address

Arlington Research Center, Inc.

Arlington, Texas, 76011

Center for Clinical Studies, Houston, Texas

Status

Address

Center for Clinical Studies

Houston, Texas, 77004

Austin Institute for Clinical Research, Pflugerville, Texas

Status

Address

Austin Institute for Clinical Research

Pflugerville, Texas, 78660

Progressive Clinical Research, San Antonio, Texas

Status

Address

Progressive Clinical Research

San Antonio, Texas, 78213

San Antonio, Texas

Status

Address

Dermatology Clinical Research Center of San Antonio

San Antonio, Texas, 78229

Center for Clinical Studies, Webster, Texas

Status

Address

Center for Clinical Studies

Webster, Texas, 77598

Cope Family Medicine - Ogden Clinic, Bountiful, Utah

Status

Address

Cope Family Medicine - Ogden Clinic

Bountiful, Utah, 84010

Frontier Derm Partners CRO, LLC, Mill Creek, Washington

Status

Address

Frontier Derm Partners CRO, LLC

Mill Creek, Washington, 98012

International Sites

Centro Privado de Medicina Familiar, Buenos Aires, Argentina

Status

Address

Centro Privado de Medicina Familiar

Buenos Aires, , C1417EYG

Conexa Investigacion Clinica S.A., Caba, Argentina

Status

Address

Conexa Investigacion Clinica S.A.

Caba, , C1012AAY

CEDIC Centro de Investigacion clinica, Caba, Argentina

Status

Address

CEDIC Centro de Investigacion clinica

Caba, , C1060ABN

CIPREC, Ciudad Autonoma de Buenos Aires, Argentina

Status

Address

CIPREC

Ciudad Autonoma de Buenos Aires, , C1061AAS

Alberta DermaSurgery Centre, Edmonton, Alberta, Canada

Status

Address

Alberta DermaSurgery Centre

Edmonton, Alberta, T6G 1C3

Lynderm Research Inc., Markham, Ontario, Canada

Status

Address

Lynderm Research Inc.

Markham, Ontario, L3P 1X3

Skin Centre for Dermatology, Peterborough, Ontario, Canada

Status

Address

Skin Centre for Dermatology

Peterborough, Ontario, K9J 5K2

Richmond Hill, Ontario, Canada

Status

Address

York Dermatology Clinic and Research Centre

Richmond Hill, Ontario, L4C 9M7

Innovaderm Research Inc., Montreal, Quebec, Canada

Status

Address

Innovaderm Research Inc.

Montreal, Quebec, H2X 2V1

Skinsense Medical Research, Saskatoon, Saskatchewan, Canada

Status

Address

Skinsense Medical Research

Saskatoon, Saskatchewan, S7K 2C1

Quebec, Canada

Status

Address

Centre De Recherche Dermatologique Du Quebec Metropolitain

Quebec, , G1V 4X7

Berlin, Germany

Status

Address

ISA - Interdisciplinary Study Association GmbH

Berlin, , 10789

Berlin, Germany

Status

Address

CRS Clinical Research Services Berlin GmbH

Berlin, , 13627

Niesmann & Othlinghaus GbR, Bochum, Germany

Status

Address

Niesmann & Othlinghaus GbR

Bochum, , 44793

Rosenpark Research GmbH, Darmstadt, Germany

Status

Address

Rosenpark Research GmbH

Darmstadt, , 64283

Dresden, Germany

Status

Address

Medizinische Fakultat Carl Gustav Carus Technische Universitat Dresden

Dresden, , 01307

Universitaetsklinikum Frankfurt, Frankfurt am Main, Germany

Status

Address

Universitaetsklinikum Frankfurt

Frankfurt am Main, , 60590

Dermatologikum Hamburg Gmbh, Hamburg, Germany

Status

Address

Dermatologikum Hamburg Gmbh

Hamburg, , 20354

Klinische Forschung Schwerin GmbH, Schwerin, Germany

Status

Address

Klinische Forschung Schwerin GmbH

Schwerin, , 19055

Hautarztpraxis, Witten, Germany

Status

Address

Hautarztpraxis

Witten, , 58453

Pecsi Tudomanyegyetem, Borgyogyaszati Klinika, Hungary

Status

Address

Pecsi Tudomanyegyetem

Borgyogyaszati Klinika, , 7632

Obudai Egeszsegugyi Centrum Kft, Budapest, Hungary

Status

Address

Obudai Egeszsegugyi Centrum Kft

Budapest, , 1036

Derma-B Kft, Debrecen, Hungary

Status

Address

Derma-B Kft

Debrecen, , 4031

Szeged, Hungary

Status

Address

SZTE AOK Szent-Gyorgyi Albert Klinikai Kozpont, Borgyogyaszati és Allergologiai Klinika

Szeged, , 6720

Allergo-Derm Bakos Kft., Szolnok, Hungary

Status

Address

Allergo-Derm Bakos Kft.

Szolnok, , 5000

Medmare Egeszsegugyi Es Szolgaltato Bt., Veszprem, Hungary

Status

Address

Medmare Egeszsegugyi Es Szolgaltato Bt.

Veszprem, , 8200

Pusan National University Hospital, Busan, Korea, Republic of

Status

Address

Pusan National University Hospital

Busan, , 49241

Gyeonggi-do, Korea, Republic of

Status

Address

Seoul National University Bundang Hospital

Gyeonggi-do, , 13620

Korea University Guro Hospital, Seoul Teugbyeolsi, Korea, Republic of

Status

Address

Korea University Guro Hospital

Seoul Teugbyeolsi, , 08308

Seoul National University Hospital, Seoul, Korea, Republic of

Status

Address

Seoul National University Hospital

Seoul, , 03080

Konkuk University Medical Center, Seoul, Korea, Republic of

Status

Address

Konkuk University Medical Center

Seoul, , 05030

Specderm Poznanska sp j, Bialystok, Poland

Status

Address

Specderm Poznanska sp j

Bialystok, , 15 375

Osteo-Medic s.c A. Racewicz, J Supronik, Bialystok, Poland

Status

Address

Osteo-Medic s.c A. Racewicz, J Supronik

Bialystok, , 15-351

Krakow, Poland

Status

Address

Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

Krakow, , 30 002

Krakow, Poland

Status

Address

Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny

Krakow, , 30-438

Centrum Medyczne Promed, Krakow, Poland

Status

Address

Centrum Medyczne Promed

Krakow, , 31-411

Dermed Centrum Medyczne Sp z o o, Lodz, Poland

Status

Address

Dermed Centrum Medyczne Sp z o o

Lodz, , 90 265

Osielsko, Poland

Status

Address

DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.

Osielsko, , 86031

SOLUMED Centrum Medyczne, Poznan, Poland

Status

Address

SOLUMED Centrum Medyczne

Poznan, , 60-529

Poznan, Poland

Status

Address

Clinical Research Center sp z o o MEDIC R s k

Poznan, , 61 731

Przychodnia Specjalistyczna High Med, Warszawa, Poland

Status

Address

Przychodnia Specjalistyczna High Med

Warszawa, , 01 817

Klinika Ambroziak Dermatologia, Warszawa, Poland

Status

Address

Klinika Ambroziak Dermatologia

Warszawa, , 02-953

Centrum Medyczne Oporow, Wroclaw, Poland

Status

Address

Centrum Medyczne Oporow

Wroclaw, , 52-416

Wrocław, Poland

Status

Address

WroMedica I.Bielicka, A.Strzałkowska s.c.

Wrocław, , 51-685

Hosp. Univ. Germans Trias I Pujol, Badalona, Spain

Status

Address

Hosp. Univ. Germans Trias I Pujol

Badalona, , 08916

Hosp. Del Mar, Barcelona, Spain

Status

Address

Hosp. Del Mar

Barcelona, , 08003

Hosp. Sant Joan de Deu, Esplugues de Llobregat, Spain

Status

Address

Hosp. Sant Joan de Deu

Esplugues de Llobregat, , 08950

Hosp. Univ. San Cecilio, Granada, Spain

Status

Address

Hosp. Univ. San Cecilio

Granada, , 18016

Hosp. Univ. 12 de Octubre, Madrid, Spain

Status

Address

Hosp. Univ. 12 de Octubre

Madrid, , 28041

Hosp. de Manises, Manises, Spain

Status

Address

Hosp. de Manises

Manises, , 46940

Hosp. Virgen Macarena, Sevilla, Spain

Status

Address

Hosp. Virgen Macarena

Sevilla, , 41009

Hosp. Univ. I Politecni La Fe, Valencia, Spain

Status

Address

Hosp. Univ. I Politecni La Fe

Valencia, , 46026

Hsin Chu, Taiwan

Status

Address

National Taiwan University Hospital Hsin-Chu Branch

Hsin Chu, , 30059

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Status

Address

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung, , 83301

National Taiwan University Hospital, Taipei, Taiwan

Status

Address

National Taiwan University Hospital

Taipei, , 10048

Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

Status

Address

Linkou Chang Gung Memorial Hospital

Taoyuan, , 33382

Konya, Turkey

Status

Address

Necmettin Erbakan University Meram Medical Faculty

Konya, , 42080

Ondokuz Mayis University, Samsun, Turkey

Status

Address

Ondokuz Mayis University

Samsun, , 55270

Trabzon, Turkey

Status

Address

Karadeniz Teknik University Medical Faculty

Trabzon, , 61080

Harrow, United Kingdom

Status

Address

London North West University Healthcare NHS Trust

Harrow, , HA1 3UJ

Salford Royal Hospital, Salford, United Kingdom

Status

Address

Salford Royal Hospital

Salford, , M6 8HD

Southampton, United Kingdom

Status

Address

University Hospital Southampton NHS Foundation Trust

Southampton, , SO16 6YD

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