A Study of LY3972406 in Adult Participants With Moderate-to-Severe Plaque Psoriasis

Study Purpose

The main purpose of this study is to determine the efficacy and safety of LY3972406 in adult participants with moderate-to-severe plaque psoriasis.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years - 75 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Have moderate-to-severe chronic plaque psoriasis for at least 6 months prior to baseline.
  • - Have venous access sufficient to allow for blood sampling.
  • - Are able to swallow oral medication.
  • - Agree to skin biopsies.

Exclusion Criteria:

  • - Have any other skin conditions, excluding plaque psoriasis.
  • - Have a current or recent acute, active infection.
  • - Have manifestations of other autoimmune diseases, such as systemic lupus erythematosus.
- Are lactating or breastfeeding women

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT06176768
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 2
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Eli Lilly and Company
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 on - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Principal Investigator Affiliation Eli Lilly and Company
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Recruiting
Countries United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Plaque Psoriasis
Arms & Interventions

Arms

Experimental: LY3972406 Dose 1

Participants will receive an oral dose of LY3972406

Experimental: LY3972406 Dose 2

Participants will receive an oral dose of LY3972406

Placebo Comparator: Placebo

Participants will receive placebo.

Interventions

Drug: - LY3972406

Administered orally

Drug: - Placebo

Administered orally

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Dermatology Research Associates, Los Angeles, California

Status

Recruiting

Address

Dermatology Research Associates

Los Angeles, California, 90045

Clinical Science Institute, Santa Monica, California

Status

Recruiting

Address

Clinical Science Institute

Santa Monica, California, 90404

Driven Research, Coral Gables, Florida

Status

Recruiting

Address

Driven Research

Coral Gables, Florida, 33134

Conquest Research, Winter Park, Florida

Status

Recruiting

Address

Conquest Research

Winter Park, Florida, 32789

East Windsor, New Jersey

Status

Recruiting

Address

Psoriasis Treatment Center of Central New Jersey

East Windsor, New Jersey, 08520

Metropolitan Dermatology - Clark, Kenilworth, New Jersey

Status

Recruiting

Address

Metropolitan Dermatology - Clark

Kenilworth, New Jersey, 07033

Accellacare - Winston-Salem, Winston-Salem, North Carolina

Status

Recruiting

Address

Accellacare - Winston-Salem

Winston-Salem, North Carolina, 27103

DermDox Centers for Dermatology, Camp Hill, Pennsylvania

Status

Recruiting

Address

DermDox Centers for Dermatology

Camp Hill, Pennsylvania, 17011

Center for Clinical Studies, Houston, Texas

Status

Recruiting

Address

Center for Clinical Studies

Houston, Texas, 77004

Austin Institute for Clinical Research, Houston, Texas

Status

Recruiting

Address

Austin Institute for Clinical Research

Houston, Texas, 77056

The content provided on clinical trials is for informational purposes only and is not a substitute for medical consultation with your healthcare provider. We do not recommend or endorse any specific study and you are advised to discuss the information shown with your healthcare provider. While we believe the information presented on this website to be accurate at the time of writing, we do not guarantee that its contents are correct, complete, or applicable to any particular individual situation. We strongly encourage individuals to seek out appropriate medical advice and treatment from their physicians. We cannot guarantee the availability of any clinical trial listed and will not be responsible if you are considered ineligible to participate in a given clinical trial. We are also not liable for any injury arising as a result of participation.